NSAIDs and cardiovascular risk
NSAIDs and cardiovascular risk
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DOI：
10.2459/jcm.0000000000000443
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发表时间：
2017-01-01
影响因子：
3
通讯作者：
Filardi, Pasquale P.
中科院分区：
文献类型：
--
作者：
Marsico, Fabio;Paolillo, Stefania;Filardi, Pasquale P.
NSAID是世界上使用最广泛的一类药物，因为它们在许多疾病中大量使用，特别是用于全身性炎症性疾病。然而，由于与这些药物相关的几种副作用，今天NSAID较少用于这些疾病中的一些。NSAID的抗炎机制在于抑制两种形式的环氧合酶，即考克斯-1（其阻断有助于抗血小板作用）和考克斯-2（其阻断具有更强的抗炎、解热和镇痛作用）。考克斯-2抑制剂可能会降低胃肠道毒性的风险，但一些研究已经显示了这种抑制剂的心血管副作用。心血管副作用的机制是有争议的，所以本文的目的是审查的副作用的非甾体抗炎药的概况，特别是，调查在临床实践中使用非甾体抗炎药的心血管后果。
NSAIDs are the most largely used class of drugs in the world, due to their large use in many diseases, in particular for the systemic inflammatory diseases. Nevertheless, today NSAIDs are less used for some of these diseases, due to several side-effects correlated to these drugs. The antiinflammatory mechanism of NSAIDs consist in the inibhition of two forms of cyclooxygenase, namely COX-1 (its block contributes to an antiplatelet effect) and COX-2 (its block has a greater antiinflammatory, antipyretic and analgesic effect). The COX-2 inhibition might reduce the risk of gastrointestinal toxicity, but several studies have shown the cardiovascular side effects of this inhibition. Mechanisms of the cardiovascular side effects are controversial yet, so the aim of this document is to review side-effects profile of NSAIDs and, specifically, to investigate cardiovascular consequences of NSAIDs use in clinical practice.