Altered Gut Microbiome and Fecal Immune Phenotype in Early Preterm Infants With Leaky Gut.
Altered Gut Microbiome and Fecal Immune Phenotype in Early Preterm Infants With Leaky Gut.
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DOI：
10.3389/fimmu.2022.815046
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发表时间：
2022
影响因子：
7.3
通讯作者：
Ma B
中科院分区：
文献类型：
--
作者：
Lemme-Dumit JM;Song Y;Lwin HW;Hernandez-Chavez C;Sundararajan S;Viscardi RM;Ravel J;Pasetti MF;Ma B
肠道屏障的不成熟或“肠道渗漏”是对早产新生儿中坏死性肠道结肠炎的敏感性免疫力有助于这一过程，但是确切的要素在很大程度上没有表征，在生物学上留下了很大的知识差距肠道成熟的基础。与肠道渗透率（IP），母乳喂养和免疫学特征相关。微生物群类型与IP升高，母乳喂养降低以及粪便细胞因子谱相关，另一方面，较低的IP与粪便IL-1α/β的水平增加有关我们的研究具有扩大的发酵能力的厌氧菌。肠道微环境影响早产新生儿的肠道体内稳态和产后肠道成熟。
Intestinal barrier immaturity, or “leaky gut”, is the proximate cause of susceptibility to necrotizing enterocolitis in preterm neonates. Exacerbated intestinal immune responses, gut microbiota dysbiosis, and heightened barrier injury are considered primary triggers of aberrant intestinal maturation in early life. Inordinate host immunity contributes to this process, but the precise elements remain largely uncharacterized, leaving a significant knowledge gap in the biological underpinnings of gut maturation. In this study, we investigated the fecal cytokine profile and gut microbiota in a cohort of 40 early preterm infants <33-weeks-gestation to identify immune markers of intestinal barrier maturation. Three distinct microbiota types were demonstrated to be differentially associated with intestinal permeability (IP), maternal breast milk feeding, and immunological profiles. The Staphylococcus epidermidis- and Enterobacteriaceae-predominant microbiota types were associated with an elevated IP, reduced breast milk feeding, and less defined fecal cytokine profile. On the other hand, a lower IP was associated with increased levels of fecal IL-1α/β and a microbiota type that included a wide array of anaerobes with expanded fermentative capacity. Our study demonstrated the critical role of both immunological and microbiological factors in the early development of intestinal barrier that collectively shape the intestinal microenvironment influencing gut homeostasis and postnatal intestinal maturation in early preterm newborns.