Integration of functional imaging in radiosurgery: the example of PET scan.
Integration of functional imaging in radiosurgery: the example of PET scan.
复制标题
放射外科中功能成像的整合：PET 扫描示例。
DOI：
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发表时间：
2007
影响因子：
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通讯作者：
S. Goldman
中科院分区：
文献类型：
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作者：
M. Levivier;N. Massager;D. Wikler;D. Devriendt;S. Goldman
放射外科关键依赖于用于靶向的成像模式。Leksell伽玛刀（LGK）放射外科在成像精度方面提出了最高要求，因为治疗是在单次高剂量治疗中应用的，除医学成像外没有其他空间控制。功能成像模式的出现为LGK规划策略带来了新的挑战。立体定向PET在LGK中的集成代表了现代多模态成像在放射外科中的这种应用的示例。我们的经验包括130名患者接受MR/CT和PET引导的联合治疗。为了分析PET的具体贡献，我们开发了一种分类，反映了用于定义靶体积的策略。当结合PET和MR信息时，定义了149个靶体积，因为一些患者存在多个病变或多灶性肿瘤区域。在88%的病变中发现PET摄取异常;使用分类，我们发现PET提供的信息显著改变了73%的肿瘤的MR定义。总之，PET在放射外科中的整合提供了额外的功能信息，为脑肿瘤的治疗开辟了新的前景。使用标准化分类可以评估PET的相对作用。一个类似的方法可能是有用的，并可能作为一个模板，在放射外科其他新的成像模式的整合评价。
Radiosurgery relies critically on the imaging modalities that are used for targeting. Leksell Gamma Knife (LGK) radiosurgery presents the highest requirements in terms of imaging accuracy as the treatment is applied in a single high-dose session with no other spatial control than medical imaging. The advent of functional imaging modalities opens new challenges for LGK planning strategies. The integration of stereotactic PET in LGK represents an example of such application of modern multimodality imaging in radiosurgery. Our experience consists of 130 patients treated with the combination of MR/CT and PET guidance. In order to analyze the specific contribution of PET, we developed a classification reflecting the strategy used to define the target volume. When combining PET and MR information, 149 target volumes were defined, because some patients presented with multiple lesions or multifocal tumor areas. Abnormal PET uptake was found in 88% of the lesions; using the classification, we found that the information provided by PET altered significantly the MR-based definition of the tumor in 73%. In conclusion, integration of PET in radiosurgery provides additional functional information opening new perspectives for the treatment of brain tumors. The use of a standardized classification allows to assess the relative role of PET. A similar approach could be useful and may serve as a template for the evaluation of the integration of other new imaging modalities in radiosurgery.
多形性胶质母细胞瘤中 18F-FDG PET 的体积分析：预后信息以及在辐射剂量递增中靶体积定义中的可能作用。
DOI：
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发表时间：
2002
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
Tralins,KevinS;Douglas,JamesG;Stelzer,KeithJ;Mankoff,DavidA;Silbergeld,DanielL;Rostomily,RobertC;Hummel,Sharon;Scharnhorst,Jeff;Krohn,KennethA;Spence,AlexanderM;Rostomilly,Robert
通讯作者：
Rostomilly,Robert