In vivo isotropic 3D diffusion tensor mapping of the rat brain using diffusion-weighted 3D MP-RAGE MRI
In vivo isotropic 3D diffusion tensor mapping of the rat brain using diffusion-weighted 3D MP-RAGE MRI
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DOI：
10.1016/j.mri.2005.12.011
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发表时间：
2006-04-01
影响因子：
2.5
通讯作者：
Hirose, T
中科院分区：
文献类型：
--
作者：
Numano, T;Homma, K;Hirose, T
本研究的目的是探讨扩散加权（DW）三维（3D）MP-MRI扩散张量映射的大鼠大脑在体内的潜力。DW-3D-MP-DWI（3D-DWI）。在2.0 T下使用6个梯度方向和1000 s/mm（2）的B值执行序列。在该序列中，使用具有“90度RF运动证明梯度（MPG）：MPG-180度RF-MPG-90度RF”脉冲序列（DW驱动平衡傅立叶变换）的制备序列来使磁化对扩散敏感。中心k空间采集顺序是必要的，以最大限度地减少来自具有短弛豫时间的组织的饱和效应（T1污染）。图像矩阵为128 X 128 X 128（从64 X 64 X 64次采集中插值），这导致小的各向同性DW图像数据（体素大小：0.273 x 0.273 x 0.273 mm（3））。此外，部分各向异性（FA），相对各向异性（RA）和主扩散方向的3D-DWI衍生的地图是完全免费的可测量性引起的信号损失和几何失真。两个著名的连合纤维，胼胝体和前连合，被指出，并显示与这些已知的立体定位图谱的位置一致。实验时间为45 min，临床应用中应尽可能缩短实验时间。3D-DWI序列允许大鼠大脑的体内3D扩散张量映射，而没有运动伪影和对失真的敏感性。(C)2006年爱思唯尔公司All rights reserved.
The purpose of this study was to examine the potential of diffusion-weighted (DW) three-dimensional (3D) MP-RAGE MRI for diffusion-tensor mapping of the rat brain in vivo. A DW-3D-MP-RAGE (3D-DWI). sequence was implemented at 2.0 T using six gradient orientations and a b value of 1000 s/mm(2). In this sequence, the preparation sequence with a "90 degrees RF-motion proving gradient (MPG): MPG-180 degrees RF-MPG-90 degrees RF" pulse train (DW driven equilibrium Fourier transform) was used to sensitize the magnetization to diffusion. A centric k-space acquisition order was necessary to minimize saturation effects (T1 contamination) from tissues with short relaxation time. The image matrix was 128 X 128 X 128 (interpolated from 64 X 64 X 64 acquisitions), which resulted in small isotropic DW image data (voxel size: 0.273 x 0.273 x 0.273 mm(3)). Moreover, 3D-DWI-derived maps of the fractional anisotropy (FA), relative anisotropy (RA) and main-diffusion direction were completely free of susceptibility-induced signal losses and geometric distortions. Two well-known commissural fibers, the corpus callosum and anterior commissure, were indicated and shown to be in agreement with the locations of these known stereotaxic atlases. The experiment took 45 min, and shorter times should be possible in clinical application. The 3D-DWI sequence allows for in vivo 3D diffusion-tensor mapping of the rat brain without motion artifacts and susceptibility to distortion. (C) 2006 Elsevier Inc. All rights reserved.