Olfactory function and olfactory bulb volume in Wilson's disease
Olfactory function and olfactory bulb volume in Wilson's disease
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DOI：
10.1007/s00405-018-5216-9
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发表时间：
2019-01-01
影响因子：
2.6
通讯作者：
Ozturan, Orhan
中科院分区：
文献类型：
--
作者：
Degirmenci, Nazan;Veyseller, Bayram;Ozturan, Orhan
目的探讨肝豆状核变性（WD）患者的嗅觉功能及嗅球体积变化。方法设计一项前瞻性、对照、单盲研究。研究对象为12例WD患者（第一组）和12例健康受试者（第二组）。采用康涅狄格化学感觉临床研究中心（CCCRC）试验评估嗅觉功能。使用1.5T General Electric signexcite MRI扫描仪测量OB体积。结果两组患者CCCRC评分比较，差异有统计学意义（p0.05）。结论嗅觉障碍患者有可能出现嗅觉功能障碍，对其进行评估可能是这些患者随访护理的有用工具，但仍需进一步研究WD演变的相关性。
PurposeTo evaluate the olfactory function and the olfactory bulb (OB) volume changes in Wilson's Disease (WD) patients.MethodsA prospective, controlled, single-blinded study was planned. 12 patients with WD (Group 1) and 12 healthy subjects (Group 2) were included in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. OB volumes were measured with a 1.5T General Electric Signa Excite MRI scanner.ResultsThere was a significant difference between the CCCRC scores of the two groups (p0.05).ConclusionsWD patients are likely to experience olfactory dysfunction, so its assessment may be a useful tool to the follow-up care of these patients, although further studies are needed to evaluate correlations in WD evolution.