Quality of life in long-term survivors of ovarian germ cell tumors: A Gynecologic Oncology Group Study
Quality of life in long-term survivors of ovarian germ cell tumors: A Gynecologic Oncology Group Study
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DOI：
10.1016/j.ygyno.2007.01.042
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发表时间：
2007-06-01
影响因子：
4.7
通讯作者：
Cella, David
中科院分区：
文献类型：
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作者：
Champion, Victoria;Williams, Stephen D.;Cella, David
目的.本报告描述了132例卵巢癌患者中4类生活质量（QOL）结果的前因变量和中介变量之间的关联强度和意义。幸存者（n = 132）参加了邮寄问卷和计算机辅助电话调查。四个前瞻性GOG方案的参与者与他们的治疗医生联系，以获得印第安纳州大学癌症中心的研究人员就生活质量研究进行口头同意。也包括在MD安德森癌症中心治疗的类似患者。如果妇女在印第安纳州大学的研究人员联系后口头同意，则通过邮件发送知情同意书和问卷包。在返回的书面知情同意书和背景调查问卷，一个训练有素的研究助理安排了一个计算机辅助的采访，以完成数据收集。诊断后的中位随访时间为10.2年。中介变量的自我效能或社会支持发挥了重要作用（p = 0.05至p = 0.001），在所有四个QOL类别：身体功能，心理功能，性功能和精神功能。诊断时年龄较小和已婚与性功能呈正相关（p = 0.05）。月经和妇科症状呈负相关。结果表明，临床医生可能要特别敏感，以确定幸存者的社会支持和信心（自我效能），在处理从治疗演变的问题，因为这些技能可能与整体生活质量的结果。(c)2007年爱思唯尔公司All rights reserved.
Purpose. This report describes the strength and significance of the association between antecedent and mediating variables across four categories of quality of life (QOL) outcomes in 132 disease free women with ovarian genii cell survivors.Methods. Survivors (n = 132) participated in a mailed questionnaire and computer-assisted telephone survey. Participants in four prospective GOG protocols were contacted their treating physician for verbal consent to be approached by investigators at the Indiana University Cancer Center about a quality of life study. similar patients treated at the MD Anderson Cancer Center were also included. If women verbally consented after being contacted by investigators at Indiana University, an informed consent and questionnaire packet was sent via mail. After return of the written informed consent and background questionnaire, a trained research assistant scheduled a computer-assisted interview to complete data collection.Results. Median follow-up from diagnosis was 10.2 years. Mediating variables of self-efficacy or social support played a significant role (p = 0.05 to p = 0.001) in all four QOL categories: physical functioning, psychological functioning, sexual functioning, and spiritual functioning. Being a younger age at diagnosis and married were positively related to sexual functioning (p = 0.05). Menstrual and gynecological symptoms were inversely related.Implications. Results indicate that clinicians may want to be especially sensitive to identifying a survivor's social support and confidence (self efficacy) in handling issues evolving from treatment since these skills may be related to overall quality of life outcomes. (c) 2007 Elsevier Inc. All rights reserved.