Ototoxicity of aminoglycoside antibiotics in infants and children
Ototoxicity of aminoglycoside antibiotics in infants and children
复制标题
氨基糖苷类抗生素对婴儿和儿童的耳毒性
DOI：
10.1097/00006454-198209000-00017
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
F. Rusconi
中科院分区：
文献类型：
--
作者：
B. Assael;R. Parini;F. Rusconi
氨基糖苷类抗生素多年来一直用于治疗婴儿和儿童的严重感染。它们对大多数革兰氏阴性肠杆菌和葡萄球菌的体外活性通常被良好的临床结果所证实。近年来，由于抗假单胞菌活性衍生物的开发和对细菌酶失活不敏感的阿米卡星的临床应用，使其活性谱得到改善。另一方面，就毒理学方面而言，似乎未获得实质性改善。事实上，常用的氨基糖苷类药物仍具有重要的剂量相关毒性作用，这一直是深入研究的对象。""
The aminoglycoside antibiotics have been used for years to treat severe infections in infants and children. Their excellent in vitro activity against most Gram-negative Enterobacteriaceae and staphylococci is usually paralleled by favorable clinical results. The dis-covery of derivatives with anti-Pseudomonas activity and the introduction in clinical practice of amikacin, which is less susceptible to inactivation by bacterial enzymes, have in recent years' led to an improved spectrum of activity. On the other hand, it seems that no substantial improvement has been obtained as far the toxicologic aspects are concerned. In fact, the aminoglycosides used commonly still have important dose-related toxic effects that have been the object of intensive investigation.""