Odor-associated health complaints: Competing explanatory models
Odor-associated health complaints: Competing explanatory models
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DOI：
10.1093/chemse/26.3.339
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发表时间：
2001-03-01
期刊：
影响因子：
3.5
通讯作者：
Shusterman, D
中科院分区：
文献类型：
--
作者：
Shusterman, D
身体症状可能在工作场所和社区环境中报告，其中存在有气味的空气传播的化学品。尽管此类报告相对频繁，但临床医生，公共卫生当局和感官科学家经常难以解释与气味相关的症状。本综述中主张的解释方法包括：（i）了解所涉及制剂的毒理学（特别是其相对刺激性和气味效力）;（ii）评估暴露参数（即浓度和持续时间）。根据暴露浓度、持续时间和相对刺激性和气味效力，可以调用多种病理生理机制来解释气味相关的健康症状。其中一些归因机制属于传统的毒理学范围，其他机制涉及对气味的态度和/或行为反应。
Physical symptoms may be reported in workplace and community settings in which odorous airborne chemicals are present. Despite the relative frequency of such reports, clinicians, public health authorities and sensory scientists often experience difficulty interpreting odor-associated symptoms. The approach to interpretation advocated in this review involves: (i) under standing the toxicology of the agent(s) involved tin particular their relative irritant and odorant potencies); (ii) assessing exposure parameters (i.e. concentration and duration). Depending upon exposure concentration, duration and relative irritant and odorant potencies, a variety of pathophysioiogical mechanisms may be invoked in explaining odor-associated health symptoms. Some of these imputed mechanisms fall under the traditional scope of toxicology and others involve attitudinal and/or behavioral responses to odors.