Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study
Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study
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DOI：
10.1700/1217.13499
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发表时间：
2012-11-01
期刊：
影响因子：
--
通讯作者：
Huang, Jian-An
中科院分区：
文献类型：
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作者：
Chen, Yan-bin;Mu, Chuan-Yong;Huang, Jian-An
目标和背景。程序性死亡1配体1（programmed death-1-ligand 1，PD-L1）在肿瘤免疫逃逸过程中发挥重要作用。非小细胞肺癌（non-small cell lung cancer，NSCLC）是世界上最具侵袭性和难治性的恶性肿瘤之一，本研究旨在探讨PD-L1在NSCLC患者中的临床意义。采用免疫组化法检测120例NSCLC石蜡包埋标本和10例良性对照组石蜡包埋标本中PD-L1的表达。在10例良性对照中未检测到PD-L1，而57.5%的NSCLC组织标本显示PD-L1表达。PD-L1表达与患者年龄、性别和组织病理学类型无关。而PD-L1表达与肿瘤细胞分化程度、肿瘤淋巴结转移（TNM）分期及患者生存期显著相关。肿瘤细胞分化差、TNM分期高与PD-L1高表达有关。PD-L1阴性NSCLC患者的5年总生存期长于PD-L1阳性患者（P
Aims and background. The programmed death-1-ligand 1 (PD-L1) has been recently suggested to play a pivotal role in the immune evasion of tumors from host immune system. In the study, we tried to reveal the clinical significance of PD-L1 in patients with non-small cell lung cancer (NSCLC), which is one of the most aggressive and intractable malignant tumors.Methods and study design. PD-L1 expression in 120 NSCLC tissue specimens and 10 benign control samples embedded with wax were retrospectively detected by immunohistochemistry.Results. No PD-L1 was detected in the 10 benign controls, whereas 57.5% of NSCLC tissue specimens showed PD-L1 expression. There was no relationship between PD-L1 expression and patient age, gender or histopathological type. However, PD-L1 expression was significantly correlated to the degree of tumor cell differentiation, stage of tumor node metastasis (TNM) and patient survival. Poor tumor cell differentiation and advanced TNM stage were related to higher PD-L1 expression. PD-L1-negative NSCLC patients had longer overall 5-year survival than PD-L1-positive patients (P