Cryptosporidium infection in infancy as a cause of malnutrition: A community study from Guinea-Bissau, West Africa
Cryptosporidium infection in infancy as a cause of malnutrition: A community study from Guinea-Bissau, West Africa
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DOI：
10.1093/ajcn/65.1.149
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发表时间：
1997-01-01
影响因子：
7.1
通讯作者：
daSilva, APJ
中科院分区：
文献类型：
--
作者：
Molbak, K;Andersen, M;daSilva, APJ
小隐孢子虫会导致发展中国家幼儿持续性腹泻。为了确定营养状况与隐孢子虫病之间的相互作用，对 1064 名 3 岁以下儿童组成的开放队列进行了为期 1441 儿童年的每周腹泻回忆访视。总共测量了 5072 次体重和 4264 次身高。获得隐孢子虫病的儿童没有低体重（P = 0.38）或低身高（P = 0.16）的倾向。婴儿期隐孢子虫病伴有男孩估计体重减轻 392 克（95% CI：247, 538 克），女孩体重减轻 294 克（95% CI：109, 479 克），分别相当于 2 岁时平均体重的 3.7% 和 2.9%。这种体重减轻并没有带来显着的追赶性增长。线性增长也显示出类似的效果（P = 0.02）。尽管有人认为，由于追赶性生长，感染对营养的影响通常是短暂的，但目前的研究表明，婴儿期的隐孢子虫病对生长具有永久性影响。
Cryptosporidium parvum causes persistent diarrhea in young children in developing countries. To determine the interaction between nutritional status and cryptosporidiosis, an open cohort of 1064 children younger than 3 y of age was followed for 1441 child-years by weekly diarrhea recall visits. A total of 5072 weight and 4264 height measurements was made. There were no tendencies of low weight (P = 0.38) or height (P = 0.16) in children who acquired cryptosporidiosis. Cryptosporidiosis in infancy was accompanied by an estimated weight loss of 392 g (95% CI: 247, 538 g) in boys and 294 g (95% CI: 109, 479 g) in girls, corresponding to 3.7% and 2.9% of mean weight, respectively, at 2 y of age. No significant catch-up growth covered for this loss in weight. A similar effect in linear growth was shown (P = 0.02). Although it has been suggested that the effect of infections on nutrition is usually transient because of catch-up growth, the present study suggests that cryptosporidiosis in infancy has a permanent effect on growth.