Metabolic, endocrine, and immune consequences of sleep deprivation.
Metabolic, endocrine, and immune consequences of sleep deprivation.
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DOI：
10.2174/1874306401105010031
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Bahammam AS
中科院分区：
文献类型：
--
作者：
Aldabal L;Bahammam AS
在过去的三到四十年里，据观察，每人每晚的平均总睡眠时间已减少到不足七小时。与此同时，全球成人和儿童中与肥胖和糖尿病相关的数字以惊人的方式增加，并且推测伴随这种睡眠行为剥夺的神经激素变化可能导致胰岛素抵抗，并随后导致糖尿病。睡眠不足与多种生理变化有关，包括皮质醇和生长素释放肽水平升高、瘦素水平降低和葡萄糖代谢受损。实验研究还表明，在睡眠不足的情况下，炎症和促炎症标记物会增加，这些标记物是身体压力的指标。这篇综述进一步阐述了这一假设，探索了这两个实体之间联系的分子基础以及导致胰岛素抵抗和糖尿病的潜在病理生理学。我们回顾了实验和流行病学研究的结果，特别研究了睡眠时间与免疫和内分泌系统之间的关系。
Over the last three to four decades, it has been observed that the average total hours of sleep have decreased to less than seven hours per person per night. Concomitantly, global figures relating to obesity and diabetes mellitus have increased in an alarming fashion in adults and children, and it has been hypothesized that neuro-hormonal changes accompanying this behavioral sleep deprivation may lead to insulin resistance and, subsequently, to diabetes mellitus. Sleep deprivation has been associated with multiple physiological changes, including increased cortisol and ghrelin levels, decreased leptin levels and impaired glucose metabolism. Experimental studies have also shown an increase in inflammatory and pro-inflammatory markers, which are indicators of body stress, under sleep deprivation. This review elaborates further on this hypothesis, exploring the molecular basis for the link between both entities and the underlying pathophysiology that results in insulin resistance and diabetes mellitus. We review the results of experimental and epidemiological studies, specifically examining the relationship between sleep duration and the immune and endocrine systems.