Bactericidal polyurethane foam mattresses: Microbiological characterization and effectiveness
Bactericidal polyurethane foam mattresses: Microbiological characterization and effectiveness
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DOI：
10.1016/j.msec.2010.03.004
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发表时间：
2010-06-15
影响因子：
7.9
通讯作者：
Fiori, M. A.
中科院分区：
文献类型：
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作者：
Dagostin, V. S.;Golcalves, D. L.;Fiori, M. A.
抗微生物化合物2.4.4。将“-三氯-2”羟基二苯醚（三氯生）、5-氯-2-甲基-4-异噻唑啉-3-酮（异噻唑酮）和双（2-吡啶基硫）锌1,1'-二氧化（吡啶硫酮锌）掺入聚氨酯泡沫基质中。使用浓度分别为0.20 wt.%、0.50 wt.%和1.00 wt.%的杀菌剂，对不同类型细菌的感染减少能力进行评价。采用琼脂扩散试验，采用倒平板技术，分析菌落形成单位（CFU）随时间的变化。初步试验采用了枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌、霍乱沙门氏菌和金黄色葡萄球菌等微生物。体外试验表明，含吡硫酮锌的聚氨酯泡沫塑料性能最好。进行了遗传毒性试验，以评估在聚氨酯中使用吡硫锌是否会对人类使用者造成伤害。还对用聚氨酯泡沫生产的床垫表面进行了微生物测试，以验证其抗菌性能。泡沫内微生物数量的显著减少表明吡硫锌作为一种抗菌剂是有效的，而遗传毒性测试则表明对使用者没有附带影响。(c) 2010 Elsevier B.V.保留所有权利。
The antimicrobial compounds 2.4.4.''-tricloro-2 '' hydroxydiphenyl ether (triclosan), 5-chloro-2-methyl-4-isothiazolin-3-one (isothiazolone) and bis(2-pyridylthio)zinc 1,1'-dioxide (zinc pyrithione) were incorporated into polyurethane foam matrixes. Concentrations of 0.20 wt.%, 0.50 wt.% and 1.00 wt.% of each biocide compound were used, and the infection reduction capacity was evaluated for different types of bacteria. The microbiological tests with polyurethane foams were performed with agar diffusion tests using the pour plate technique and analyzing the colony formation units (CFU) as a function of time. In preliminary tests, the micro-organisms Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella choleraesuis and Staphylococcus aureus were used. Tests in vitro showed that polyurethane foam containing zinc pyrithione gave the best performance. Genotoxicity tests were conducted to evaluate if the use of zinc pyrithione in the polyurethane causes harm to human users. Microbiological tests were also performed on the surfaces of mattresses that were produced with polyurethane foam to verify their antimicrobial properties. The significant decrease in the number of micro-organisms within the foam showed the effectiveness of the zinc pyrithione as an antimicrobial, while the genotoxicity tests demonstrated the absence of collateral effects for the users. (c) 2010 Elsevier B.V. All rights reserved.