Assessing effectiveness in acne clinical trials: steps towards a core outcome measure set.
Assessing effectiveness in acne clinical trials: steps towards a core outcome measure set.
复制标题
评估痤疮临床试验的有效性：制定核心结果衡量标准的步骤。
DOI：
10.1111/bjd.18011
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Tan,J
中科院分区：
文献类型：
--
作者：
Thiboutot,DM;Layton,AM;Chren,M-M;Eady,EA;Tan,J
在全球皮肤病负担中，痤疮排名第二，仅次于皮炎。因此，至关重要的是，以一种能够最大限度地进行治疗之间比较的方式产生有关治疗疗效的数据。开发用于临床试验的核心结果集以标准化皮肤病数据收集的兴趣正在激增。本综述的目的是提供正在进行的努力，遇到的挑战和未来方向的痤疮核心结局指标的发展，用于临床试验。方法痤疮核心结果研究网络（ACORN）的活动是在目前可接受的核心结果集开发方法的背景下提出的。结论：重点是遵循严格的方法，让患者参与其中，并认识到新兴技术的作用。
BackgroundAcne ranks second to dermatitis in terms of global burden of skin disease. As such, it is essential that data on treatment efficacy are generated in a way that maximizes the opportunity for comparison among treatments. Interest in developing core outcome sets for use in clinical trials to standardize data collection in skin disease is surging.ObjectivesThe goal of this review is to provide an update on the efforts underway, challenges encountered and future directions in the development of an acne core outcome measure set for use in clinical trials.MethodsThe activities of the Acne Core Outcomes Research Network (ACORN) are presented in the context of currently acceptable methodologies for core outcome set development.ConclusionsEmphasis is placed on following a rigorous methodology, involving patients and recognizing a role for emerging technologies.