OLFACTORY RECOGNITION - DIFFERENTIAL IMPAIRMENTS IN EARLY AND LATE HUNTINGTONS AND ALZHEIMERS DISEASES
OLFACTORY RECOGNITION - DIFFERENTIAL IMPAIRMENTS IN EARLY AND LATE HUNTINGTONS AND ALZHEIMERS DISEASES
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DOI：
10.1080/01688638708405208
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发表时间：
1987-12-01
影响因子：
2.2
通讯作者：
FOLSTEIN, SE
中科院分区：
文献类型：
--
作者：
MOBERG, PJ;PEARLSON, GD;FOLSTEIN, SE
对42例Alzheimer型老年性痴呆（SDAT）、38例亨廷顿病（HD）患者及配对的正常对照进行了嗅觉、言语和视觉识别测试。早期受影响的亨廷顿氏病患者（EHD）有轻微的舞蹈病或认知缺陷，尽管语言和视觉表现正常，但在嗅觉识别方面表现出明显的缺陷，即使在纠正任务困难之后，也是如此，这表明在疾病过程的早期涉及嗅觉脑区。在早期阿尔茨海默氏症组（EAD）中，所有识别模式均出现明显缺陷，表明更多的全球性损害。两个整体（早期加晚期）患者组受损相对于控制所有的识别任务，嗅觉范式受到最大的影响。
Forty-two patients with senile dementia of the Alzheimer type (SDAT), 38 patients with Huntington''s disease (HD) and matched normal controls were administered tests of olfactory, verbal, and visual recognition after being screened for normal olfactory discrimination. Early-affected Huntington''s patients (EHD) with minimal chorea or congitive deficit displayed marked deficits in olfactory recognition despite normal verbal and visual performance, even after correction for task difficulty, suggesting involvement of olfactory brain regions early in the disease process. In the early Alzheimer''s group (EAD), marked deficits were seen on all recognition modalities indicating more global impairment. Both overall (early plus late) patient groups were impaired relative to controls on all recognition tasks, with the olfactory paradigm being most affected.