Role of calcium in regulating primary sensory neuronal excitability.
Role of calcium in regulating primary sensory neuronal excitability.
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DOI：
10.1007/978-3-540-79090-7_16
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Weinreich, D
中科院分区：
文献类型：
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作者：
Gover, T D;Moreira, T H;Weinreich, D
钙离子（Ca（2+））在可兴奋组织（蛙心）中的基本作用，最早是由悉尼·林格（Sydney Ringer）在19世纪后半叶的一系列经典报告中证实的（1882 a，B; 1893 a，B）。即便如此，在证明Ca（2+）调节初级感觉神经元的兴奋性之前，已经过了将近世纪。在本章中，我们回顾了内部和外部Ca（2+）可以直接或间接改变初级感觉神经元兴奋性的部位和机制：兴奋性的变化通常表现为动作电位形状或放电模式的变化。
The fundamental role of calcium ions (Ca(2+)) in an excitable tissue, the frog heart, was first demonstrated in a series of classical reports by Sydney Ringer in the latter part of the nineteenth century (1882a, b; 1893a, b). Even so, nearly a century elapsed before it was proven that Ca(2+) regulated the excitability of primary sensory neurons. In this chapter we review the sites and mechanisms whereby internal and external Ca(2+) can directly or indirectly alter the excitability of primary sensory neurons: excitability changes being manifested typically by variations in shape of the action potential or the pattern of its discharge.