Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes.
Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes.
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位于小鼠 17 号染色体 t 复合物区域的两个乙酰辅酶 A 乙酰转移酶基因与 Tcp-1 和 Tcp-1x 基因部分重叠。
DOI：
10.1006/geno.1993.1454
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发表时间：
1993
期刊：
影响因子：
4.4
通讯作者：
A. Ashworth
中科院分区：
文献类型：
--
作者：
A. Ashworth
Tcp-1基因位于小鼠17号染色体的t复合体区域和人类6号染色体的长臂上。在小鼠中，一个相关的基因Tcp-1x与Tcp-1紧密相连。本文表明，位于鼠Tcp-1和Tcp-1x基因3'端的两个基因编码与乙酰辅酶A乙酰转移酶高度同源的蛋白质。这些基因（Acat-1和Acat-2）与Tcp-1基因的方向相反，转录导致mRNA种类在各自Acat mRNA的3'非翻译区内含有Tcp-1或Tcp-1x的最后一个外显子。这两个Acat基因似乎在几个小鼠组织中转录。ACAT基因也与人类的TCP 1基因重叠，这表明这种密切的连锁可能具有某些功能意义。
The Tcp-1 gene is located in the t-complex region of mouse chromosome 17 and on the long arm of human chromosome 6. In the mouse, a related gene, Tcp-1x, is tightly linked to Tcp-1. It is shown here that two genes located 3' to the murine Tcp-1 and Tcp-1x genes code for proteins highly homologous to acetyl-CoA acetyltransferases. These genes (Acat-1 and Acat-2) are in the opposite orientation to the Tcp-1 genes, and transcription results in mRNA species that contain the last exon of Tcp-1 or Tcp-1x within the 3' untranslated region of the respective Acat mRNA. Both Acat genes appear to be transcribed in several mouse tissues. An ACAT gene also overlaps the TCP1 gene in humans, suggesting that this close linkage may have some functional significance.