Laser-probe-based investigation of the evolution of particle size distributions of calcium oxalate particles formed in artificial urines
Laser-probe-based investigation of the evolution of particle size distributions of calcium oxalate particles formed in artificial urines
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DOI：
10.1016/s0022-0248(01)01547-0
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发表时间：
2001-11-01
影响因子：
1.8
通讯作者：
Hesse, A
中科院分区：
文献类型：
--
作者：
Laube, N;Mohr, B;Hesse, A
草酸钙肾结石形成的机制尚不清楚。在泌尿学基础研究中，我们将草酸铵加入到CaCl2样品溶液和人工尿液中，诱导草酸钙晶体的形成，草酸钙晶体是尿路中最常见的晶体。使用在线激光探针，我们在1小时内实时读取了粒径在0.5至250 μ m之间的颗粒的PSD演变（间隔4分钟）。大多数颗粒的粒径在0.5至14 μ m之间。粒径模式约为2 μ m。随时间变化的PSD显影取决于溶液的组成。在线激光探针允许个别的微小粒子的分析，其落在较低的库尔特计数器检测限制。由于这些颗粒构成了改变颗粒大小的所有进一步过程的基础，因此它们在泌尿系结石研究中具有重要意义。(C) 2001 Elsevier Science B.V.版权所有
The mechanisms for the formation of calcium oxalate kidney stones are not well understood. In our urological basic research study, ammonium oxalate was added to sample solutions of CaCl2 and to artificial urines to induce the formation of calcium oxalate crystals, the most common crystals in the urinary tract. Using an in-line laser-probe we took real-time readings (4 min intervals) of the PSD evolution of particles ranging in size between 0.5 and 250 mum over a period of 1 h. Most particles were between 0.5 and 14 mum in size. The particle-size mode is approximately 2 mum. The time-dependent PSD development depends on the composition of the solution. The in-line laser-probe permits individual analysis of minute particles which fall below the lower coulter counter detection limit. As these particles form the basis of all further processes which alter the particle size, they are of paramount interest in urinary stone research. (C) 2001 Elsevier Science B.V. All rights reserved.