Serum anion gap, bicarbonate and biomarkers of inflammation in healthy individuals in a national survey.
Serum anion gap, bicarbonate and biomarkers of inflammation in healthy individuals in a national survey.
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DOI：
10.1503/cmaj.090329
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发表时间：
2010-02-09
期刊：
影响因子：
--
通讯作者：
Taylor, Eric N
中科院分区：
文献类型：
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作者：
Farwell, Wildon R;Taylor, Eric N
BACKGROUND: In vitro data suggest that lower extracellular pH activates the immune system. We conducted a population-based study of the relation between serum acid-base status and inflammation.METHODS: We examined the serum anion gap and serum levels of bicarbonate and inflammatory biomarkers in 4525 healthy adults who participated in the National Health and Nutrition Examination Survey during 1999-2006. We excluded participants who had chronic disease, recent infection and an estimated glomerular filtration rate of less than 60 mL/min per 1.73 m2.RESULTS: The mean values of serum anion gap, bicarbonate level, leukocyte count and C-reactive protein level were all within normal limits. After adjustment for age, sex, ethnic background, body mass index, serum albumin level and other factors, we found that a higher anion gap and lower bicarbonate level were associated with a higher leukocyte count and higher C-reactive protein level. Compared with participants in the lowest quartile of anion gap, those in the highest quartile had a leukocyte count that was 1.0x10(9)/L higher and a C-reactive protein level that was 10.9 nmol/L higher (p
