Myocardial T1 mapping at 3.0 tesla using an inversion recovery spoiled gradient echo readout and bloch equation simulation with slice profile correction (BLESSPC) T1 estimation algorithm.
Myocardial T1 mapping at 3.0 tesla using an inversion recovery spoiled gradient echo readout and bloch equation simulation with slice profile correction (BLESSPC) T1 estimation algorithm.
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DOI：
10.1002/jmri.24999
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Hu P
中科院分区：
文献类型：
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作者：
Shao J;Rapacchi S;Nguyen KL;Hu P
目的：利用3.0T反转恢复扰相梯度回波读出技术，建立一种准确、精确的心肌T1标测技术。修改了改良的Look-Phase反转-恢复（MOLLI）序列，以使用快速低角度拍摄（FLASH）读出，并结合BLESSPC（Bloch方程模拟与切片轮廓校正）T1估计算法，用于准确的心肌T1标测。基于模拟、体模研究和10名健康志愿者和3名患者在3.0T下的体内研究，将FLASH-MOLLI与BLESSPC拟合在T1估计准确度、精度和图像伪影方面与不同方法和序列进行了比较。在体模研究中，FLASH-MOLLI与BLESSPC拟合可在236-1852 ms的T1和40-100 bpm的心率范围内获得准确的T1估计（平均误差= −5.4±15.1 ms，百分比误差= −0.5%±1.2%）。FLASH-MOLLI序列在3.0T下防止了所有10名健康志愿者的非共振伪影。在体内，FLASH-MOLLI衍生的心肌T1值与“ShMOLLI+IE”衍生的值之间没有显著差异（1458.9±20.9 ms vs. 1464.1±6.8 ms，p=0.50）;然而，FLASH-MOLLI的平均精确度显著优于“ShMOLLI+IE”产生的平均精确度（1.84±0.36%方差对3.57± 0.94%，p<0.001）。FLASH-MOLLI与BLESSPC拟合可产生准确和精确的T1估计，并消除3.0T下与bSSFP相关的条带伪影。
To develop an accurate and precise myocardial T1 mapping technique using an inversion recovery spoiled gradient echo readout at 3.0T. The modified Look-Locker inversion-recovery (MOLLI) sequence was modified to use fast low angle shot (FLASH) readout, incorporating a BLESSPC (Bloch Equation Simulation with Slice Profile Correction) T1 estimation algorithm, for accurate myocardial T1 mapping. The FLASH-MOLLI with BLESSPC fitting was compared to different approaches and sequences with regards to T1 estimation accuracy, precision and image artifact based on simulation, phantom studies, and in vivo studies of 10 healthy volunteers and 3 patients at 3.0T. The FLASH-MOLLI with BLESSPC fitting yields accurate T1 estimation (average error = −5.4±15.1 ms, percentage error = −0.5%±1.2%) for T1 from 236–1852 ms and heart rate from 40–100 bpm in phantom studies. The FLASH-MOLLI sequence prevented off-resonance artifacts in all 10 healthy volunteers at 3.0T. In vivo, there was no significant difference between FLASH-MOLLI-derived myocardial T1 values and “ShMOLLI+IE” derived values (1458.9±20.9 ms vs. 1464.1±6.8 ms, p=0.50); However, the average precision by FLASH-MOLLI was significantly better than that generated by “ShMOLLI+IE” (1.84±0.36% variance vs. 3.57±0.94%, p<0.001). The FLASH-MOLLI with BLESSPC fitting yields accurate and precise T1 estimation, and eliminates banding artifacts associated with bSSFP at 3.0T.