Dietary restriction alters demographic but not behavioral aging in Drosophila
Dietary restriction alters demographic but not behavioral aging in Drosophila
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DOI：
10.1111/j.1474-9726.2007.00320.x
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发表时间：
2007-10-01
期刊：
影响因子：
7.8
通讯作者：
Grotewiel, Michael S.
中科院分区：
文献类型：
--
作者：
Bhandari, Poonam;Jones, Melanie A.;Grotewiel, Michael S.
饮食限制在包括果蝇在内的许多物种中大大延长了寿命。然而，目前还不清楚饮食限制是否会影响与年龄相关的功能下降以及对寿命的影响。在这里，我们解决这个问题，通过评估饮食限制对寿命和行为衰老的影响，在两个野生型菌株，在我们的标准白色实验室股票，并在短寿命的苍蝇与超氧化物歧化酶2的表达减少。正如预期的那样，饮食限制延长了所有这些菌株的寿命。饮食限制对寿命的影响因遗传背景而异，在测试的7个菌株中，中位寿命延长了40%至90%。有趣的是，尽管饮食限制对寿命有强大的积极影响，但在我们的研究中，饮食限制对任何品系的行为衰老都没有实质性影响。我们的研究结果表明，饮食限制不会对果蝇的衰老产生全球性影响，并支持寿命和行为衰老不是由相同机制驱动的假设。
Dietary restriction extends lifespan substantially in numerous species including Drosophila. However, it is unclear whether dietary restriction in flies impacts age-related functional declines in conjunction with its effects on lifespan. Here, we address this issue by assessing the effect of dietary restriction on lifespan and behavioral senescence in two wild-type strains, in our standard white laboratory stock, and in short-lived flies with reduced expression of superoxide dismutase 2. As expected, dietary restriction extended lifespan in all of these strains. The effect of dietary restriction on lifespan varied with genetic background, ranging from 40 to 90% extension of median lifespan in the seven strains tested. Interestingly, despite its robust positive effects on lifespan, dietary restriction had no substantive effects on senescence of behavior in any of the strains in our studies. Our results suggest that dietary restriction does not have a global impact on aging in Drosophila and support the hypothesis that lifespan and behavioral senescence are not driven by identical mechanisms.