Visualization of Endolymphatic Hydrops in Meniere's Disease after Single-dose Intravenous Gadolinium-based Contrast Medium: Timing of Optimal Enhancement
Visualization of Endolymphatic Hydrops in Meniere's Disease after Single-dose Intravenous Gadolinium-based Contrast Medium: Timing of Optimal Enhancement
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DOI：
10.2463/mrms.11.43
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发表时间：
2012-01-01
影响因子：
3
通讯作者：
Nakashima, Tsutomu
中科院分区：
文献类型：
--
作者：
Naganawa, Shinji;Yamazaki, Masahiro;Nakashima, Tsutomu
目的：在静脉注射单剂量钆造影剂（GBCM） 4小时后，通过重t -2加权的三维液体衰减反转恢复（hT(2)W-3D-FLAIR），可以可视化梅尼埃病（MD）患者的内淋巴积液（EH）。虽然在健康志愿者中，对比剂给药后4小时有最大增强的报道，但在MD患者中，最佳增强的时间没有报道。我们调查了最佳时间是早于还是晚于4小时。材料和方法：我们评估了10例疑似MD患者，随机分为两组。之前我们获得hT (2) W-3D-FLAIR GBCM管理和10分钟,3.5小时,4小时后GBCM管理组在10分钟之前,4小时,4.5小时后GBCM政府在B组我们比较信号强度比(先生)的值之间的外淋巴和脑桥3.5和4个小时在A组和B组4和4.5小时之间和评价等级的呃在3.5和4个小时在A组和4和4.5小时B.Results组:爵士值3.5和4小时之间没有显著差异组A和4和4.5小时之间组b .然而,爵士值在4小时在A组明显高于b组成绩之间的嗯同意3.5和4个小时在A组和4和4.5小时B.Conclusion组:对比度增强的最佳时机在疑似MD患者尚不清楚,但评价嗯可能从3.5到4.5小时。
Purpose: Visualization of endolymphatic hydrops (EH) in patients with Meniere's disease (MD) is now possible by heavily T-2-weighted 3-dimensional fluid-attenuated inversion recovery (hT(2)W-3D-FLAIR) obtained 4 hours after intravenous (IV) administration of single dose gadolinium-based contrast medium (GBCM). Although maximum enhancement has been reported 4 hours after contrast administration in healthy volunteers, the timing of optimal enhancement in patients with MD is not reported. We investigated if that optimal timing is earlier or later than 4 hours.Materials and Methods: We evaluated 10 consecutive patients with suspected MD whom we randomly divided into 2 groups. We obtained hT(2)W-3D-FLAIR before GBCM administration and 10 min, 3.5 hours, and 4 hours after GBCM administration in Group A and before and 10 min, 4 hours, and 4.5 hours after GBCM administration in Group B. We compared signal intensity ratio (SIR) values of the perilymph and pons between 3.5 and 4 hours in Group A and between 4 and 4.5 hours in Group B and evaluated grades of EH at 3.5 and 4 hours in Group A and at 4 and 4.5 hours in Group B.Results: SIR values did not differ significantly between 3.5 and 4 hours in Group A and between 4 and 4.5 hours in Group B. However, SIR values at 4 hours were significantly higher in Group A than Group B. Grades of EH agreed between 3.5 and 4 hours in Group A and between 4 and 4.5 hours in Group B.Conclusion: The optimal timing of contrast enhancement in patients with suspected MD remains unclear, but evaluation of EH may be possible from 3.5 to 4.5 hours after contrast administration.