Pyroptosis in Cancer: Friend or Foe?
Pyroptosis in Cancer: Friend or Foe?
复制标题
癌症焦亡：朋友还是敌人？
DOI：
10.3390/cancers13143620
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发表时间：
2021-07-20
期刊：
影响因子：
5.2
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Lu X;Guo T;Zhang X
Pyroptosis是一种新形式的程序性细胞死亡，与凋亡不同的是其释放的炎症因子和其特征性的气泡样形态。Pyroptosis最初是在对细菌感染的免疫防御过程中发现的，但研究领域很快扩展到其他炎症性疾病和癌症。由于癌症对公众健康构成严重威胁，这些年来进行了许多研究，调查癌症中的焦亡。肿瘤发生和新的治疗方法一直是最近许多研究的焦点。本文就细胞凋亡在肿瘤发生中的作用及其对肿瘤免疫的影响作一综述。摘要焦亡是一种由成孔蛋白如Gasdermin家族（GSDMA-E）介导的炎症性细胞程序性死亡。在被活化的半胱天冬酶或颗粒酶蛋白酶切割后，GSDM的N-末端在膜中寡聚化以形成孔，从而导致焦亡。虽然所有的gasdermin蛋白质都在癌症中进行了研究，但pyroptosis在癌症中的作用仍然是神秘的，结果相互矛盾。大量研究表明，当细胞表达GSDM时，各种刺激，如病原体相关分子模式（PAMP），损伤相关分子模式（DAMP）和化疗药物，可以触发细胞凋亡。然而，目前尚不清楚由化疗药物或CAR T细胞治疗诱导的癌症中的焦亡对于抗肿瘤免疫是有益还是有害。本文综述了焦亡的发现及其在炎症性疾病和癌症中的作用，重点是肿瘤免疫。
Simple Summary Pyroptosis is a new form of programmed cell death that differs from apoptosis in terms of its release of inflammatory factors and its characteristic bubble-like morphology. Pyroptosis was first discovered in the process of immune defense against bacterial infection, but the field of research soon spread to other inflammatory diseases and cancer. As cancer constitutes a serious risk for public health, numerous studies investigating pyroptosis in cancer have been carried out during these years. Tumorigenesis and new therapeutic treatments have been the focus of much recent research. This review discusses the role of pyroptosis in tumorigenesis and its influence on tumor immunity. Abstract Pyroptosis is an inflammatory form of programmed cell death that is mediated by pore-forming proteins such as the gasdermin family (GSDMs), including GSDMA-E. Upon cleavage by activated caspases or granzyme proteases, the N-terminal of GSDMs oligomerizes in membranes to form pores, resulting in pyroptosis. Though all the gasdermin proteins have been studied in cancer, the role of pyroptosis in cancer remains mysterious, with conflicting findings. Numerous studies have shown that various stimuli, such as pathogen-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), and chemotherapeutic drugs, could trigger pyroptosis when the cells express GSDMs. However, it is not clear whether pyroptosis in cancer induced by chemotherapeutic drugs or CAR T cell therapy is beneficial or harmful for anti-tumor immunity. This review discusses the discovery of pyroptosis as well as its role in inflammatory diseases and cancer, with an emphasis on tumor immunity.
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影响因子：
14.2
作者：
Ferreira, Manuel A. R.;Matheson, Melanie C.;Tang, Clara S.;Granell, Raquel;Ang, Wei;Hui, Jennie;Kiefer, Amy K.;Duffy, David L.;Baltic, Svetlana;Danoy, Patrick;Bui, Minh;Price, Loren;Sly, Peter D.;Eriksson, Nicholas;Madden, Pamela A.;Abramson, Michael J.;Holt, Patrick G.;Heath, Andrew C.;Hunter, Michael;Musk, Bill;Robertson, Colin F.;Le Souef, Peter;Montgomery, Grant W.;Henderson, A. John;Tung, Joyce Y.;Dharmage, Shyamali C.;Brown, Matthew A.;James, Alan;Thompson, Philip J.;Pennell, Craig;Martin, Nicholas G.;Evans, David M.;Hinds, David A.;Hopper, John L.
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影响因子：
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影响因子：
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通讯作者：
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影响因子：
4.5
作者：
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通讯作者：
Roecken, Christoph
影响因子：
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