Modeling the dynamics of human hair cycles by a follicular automaton
Modeling the dynamics of human hair cycles by a follicular automaton
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DOI：
10.1073/pnas.97.15.8328
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发表时间：
2000-07-18
影响因子：
11.1
通讯作者：
Goldbeter, A
中科院分区：
文献类型：
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作者：
Halloy, J;Bernard, BA;Goldbeter, A
毛囊周期依次经历生长期、退化期、休止期和潜伏期，这四个阶段分别对应。在新的生长期开始之前，毛发生长、停滞、脱落和消失。通过对10名男性志愿者(脱发和非脱发)14年来的实验观察，我们可以确定头皮毛囊周期的特征。基于这些观察结果，我们提出了一个毛囊自动机模型来模拟人类头发周期的动态。自动机模型是由一组规则定义的，这些规则管理每个毛囊在连续状态生长期、休止期和潜伏期之间的随机转换，以及随后返回生长期，在由均值和方差特征的分布随机给定的时间间隔之后，每个毛囊独立地发生这些转换。毛囊自动机模型既解释了在单个毛囊中观察到的动态转变，也解释了一组独立循环的毛囊的行为。因此，该模型成功地再现了三个阶段中每个阶段毛囊种群比例的演变，这些毛囊种群在稳定状态或缓慢漂移的值附近波动。我们应用卵泡自动机模型来研究卵泡生长的空间模式，这些模式是由生长期的平均持续时间等参数的空间异质性分布引起的。当考虑到毛囊在经历了关键数量的连续周期后死亡或小型化时，该模型可以再现类似于众所周知的弥漫性或雄激素性脱发类型的毛发模式的进化。
The hair follicle cycle successively goes through the anagen, catagen, telogen, and latency phases, which correspond, respectively. to hair growth, arrest, shedding, and absence before a new anagen phase is initiated. Experimental observations collected over a period of 14 years in a group of 10 male volunteers, alopecic and nonalopecic, allowed us to determine the characteristics of scalp hair follicle cycles. On the basis of these observations, we propose a follicular automaton model to simulate the dynamics of human hair cycles. The automaton model is defined by a set of rules that govern the stochastic transitions of each follicle between the successive states anagen, telogen, and latency, and the subsequent return to anagen, The transitions occur independently for each follicle, after time intervals given stochastically by a distribution characterized by a mean and a variance. The follicular automaton model accounts both for the dynamical transitions observed in a single follicle and for the behavior of an ensemble of independently cycling follicles. Thus, the model successfully reproduces the evolution of the fractions of follicle populations in each of the three phases, which fluctuate around steady-state or slowly drifting values. We apply the follicular automaton model to the study of spatial patterns of follicular growth that result from a spatially heterogeneous distribution of parameters such as the mean duration of anagen phase. When considering that follicles die or miniaturize after going through a critical number of successive cycles, the model can reproduce the evolution to hair patterns similar to well known types of diffuse or androgenetic alopecia.