Tandem Synthesis of 2-Azaspiro[4.5]deca-1,6,9-trien-8-ones Based on Tf2O-Promoted Activation of N-(2-Propyn-1-yl) Amides.
Tandem Synthesis of 2-Azaspiro[4.5]deca-1,6,9-trien-8-ones Based on Tf2O-Promoted Activation of N-(2-Propyn-1-yl) Amides.
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DOI：
10.1021/acs.joc.2c02504
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发表时间：
2022-12
期刊：
影响因子：
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通讯作者：
L. Shan;Hongchen Li;Weiping Zheng;Xingyong Wang;Xinyan Wang-;Yuefei Hu
中科院分区：
文献类型：
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作者：
L. Shan;Hongchen Li;Weiping Zheng;Xingyong Wang;Xinyan Wang-;Yuefei Hu
Structurally novel 2-azaspiro[4.5]deca-1,6,9-trien-8-ones were synthesized from N-(2-propyn-1-yl) amides and 1,3,5-trimethoxybenzenes by a tandem method consisting of a Tf2O-promoted amide activation and a TfOH-promoted Friedel-Crafts ipso-cyclization. The method offered the first example of using N-(2-propyn-1-yl) amides as substrates in both Tf2O-promoted secondary amide activation and the synthesis of azaspiro[4.5]deca-6,9-diene-8-ones.
