Clip compression injury in the spinal cord: A correlative study of neurological and morphological alterations
Clip compression injury in the spinal cord: A correlative study of neurological and morphological alterations
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DOI：
10.1006/exnr.1997.6481
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发表时间：
1997-06-01
影响因子：
5.3
通讯作者：
Sundstrom, E
中科院分区：
文献类型：
--
作者：
vonEuler, M;Seiger, A;Sundstrom, E
实验性动脉瘤夹致大鼠脊髓不同程度压迫，伤后3周和5周进行神经功能学检查。随着时间的推移，脊髓组织破坏的发展与其他实验性脊髓损伤相似，具有早期水肿、轴突肿胀和后期坏死等特征。损伤后三周，在损伤中心发现反应性胶质增生，在坏死的空腔中可以识别再生轴突。退变的程度与动脉瘤夹的闭合力高度相关。许多神经学检查的结果与夹引起的压迫程度、病变体积和震中剩余的白色物质面积相关。与形态学描述符相关性最高的神经学测试是平衡木行走（r（s）= 0.89-0.95）和运动性能评分（r（s）= 0.88-0.92）。我们的结论是，运动性能评分，以前验证光化学诱导的缺血性脊髓损伤，同样适用于夹压迫损伤作为一个快速和可靠的神经测试范例。(C)北京：科学出版社.
Rats subjected to experimental spinal cord compression of different degrees induced by aneurysm clips were neurologically tested 3 and 5 weeks postinjury. The development of spinal cord tissue destruction over time was similar to what has been described for other experimental spinal cord injuries with characteristics such as early edema, axonal swelling, and later necrosis. Three weeks after injury a reactive gliosis was found at the injury epicenter and regenerating axons could be identified in the otherwise necrotic cavity. The extent of degeneration was highly correlated with the closing force of the aneurysm clip. The results of a number of neurological tests were correlated to the degree of clip-induced compression, to lesion volume, and to the remaining area of white matter at the epicenter. The neurological tests with the highest correlation to morphological descriptors were beam walk (r(s) = 0.89-0.95) and motor performance score (r(s) = 0.88-0.92). We conclude that the motor performance score, previously validated for photochemically induced ischemic spinal cord injuries, is equally suitable for clip compression injuries as a fast and reliable neurological test paradigm. (C) 1997 Academic Press.