In vivo alteration in type-1 and type-2 cytokine balance:: A possible mechanism for elevated total IgE in HIV-infected patients
In vivo alteration in type-1 and type-2 cytokine balance:: A possible mechanism for elevated total IgE in HIV-infected patients
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DOI：
10.1016/s0198-8859(97)00261-9
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发表时间：
1998-02-01
期刊：
影响因子：
2.7
通讯作者：
Marshall, GD
中科院分区：
文献类型：
--
作者：
Agarwal, SK;Marshall, GD
HIV 感染的进展与血浆总 IgE 水平的增加有关。 ISE 增加的机制尚未阐明。与 HIV 感染相关的 1 型和 2 型细胞因子失衡已被认为是 IgE 升高的可能机制。目前的研究旨在调查来自大量 HIV + 患者群体的总 IgE、1 型和 2 型细胞因子之间的关系。 HIV+ 患者的总 IgE 升高，与 CD4+ T 细胞的数量呈负相关。与 HIV 阴性个体相比，HIV+ 血浆中的 IFN-γ 和 IL-12p70 水平降低，而 IL-10 水平升高。根据绝对 CD4+ 计数定义，患有更晚期疾病的 HIV+ 患者表现出更显着的差异。此外，与 HIV 阴性个体相比，HIV+ 患者中 IFN-γ:IL-10 和 IL-12:IL-10 的相对比率降低。血浆细胞因子的变化表明从 1 型细胞因子为主转变为 2 型细胞因子，这可能会增强 IgE 合成。这些数据表明，血浆 IgE 和/或细胞因子的测量可能对 HIVS 患者具有预后或治疗监测价值。 (C) 美国组织相容性和免疫遗传学学会，1998 年。由 Elsevier Science Inc. 出版。
The progression of HIV infection has been associated with an increase in the plasma levels of total IgE. The mechanisms responsible for the increased ISE have not been elucidated. The type-1 and type-2 cytokine imbalance associated with HIV infection has been proposed as a possible mechanism for elevated IgE, The current study was undertaken to investigate the relationship between total IgE, type-1 and type-2 cytokines from a large HIV+ patient population. HIV+ patients were found to have elevated total IgE that inversely correlated with numbers of CD4+ T-cells. HIV+ plasma was also found to have decreased IFN-gamma and IL-12p70 levels as well as increased IL-10 levels compared to HIV-negative individuals. HIV+ patients with more advanced disease, as defined by absolute CD4+ counts, demonstrated more marked differences, Furthermore, the relative ratios of IFN-gamma:IL-10 and IL-12:IL-10 were decreased in HIV+ patients compared to HIV-negative individuals. The alterations in the plasma cytokines suggest a switch from a predominance of type-1 cytokines to type-2 cytokines that may enhance IgE synthesis. These data suggest that measurement of plasma IgE and/or cytokines may have prognostic or therapeutic monitoring value in HIVS patients. (C) American Society for Histocompatibility and Immunogenetics, 1998. Published by Elsevier Science Inc.