Intracellular signalling - Key enzyme in leptin-induced anorexia
Intracellular signalling - Key enzyme in leptin-induced anorexia
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DOI：
10.1038/35101657
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发表时间：
2001-10-25
期刊：
影响因子：
64.8
通讯作者：
Schwartz, MW
中科院分区：
文献类型：
--
作者：
Niswender, KD;Morton, GJ;Schwartz, MW
瘦素是能量平衡的关键激素调节剂，作用于下丘脑神经元以减少食物摄入，但所涉及的细胞内机制尚不完全清楚。在这里，我们表明，大鼠全身给予瘦素激活下丘脑中的磷脂酰肌醇-3-OH激酶（PI（3）K），脑室内（i. c. v.）输注该酶的抑制剂可预防瘦素诱导的厌食症。我们的研究结果表明，PI（3）K是一个关键的酶的信号转导途径，连接下丘脑瘦素减少食物摄入量。
Leptin is a key hormonal regulator of energy balance that acts upon hypothalamic neurons to reduce food intake, but the intracellular mechanisms involved are incompletely understood. Here we show that systemic administration of leptin in rats activates the enzyme phosphatidylinositol-3-OH kinase (PI(3)K) in the hypothalamus and that intracerebro-ventricular (i.c.v.) infusion of inhibitors of this enzyme prevents leptin-induced anorexia. Our results indicate that PI(3)K is a crucial enzyme in the signal-transduction pathway that links hypothalamic leptin to reduced food intake.