Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants
Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants
复制标题
DOI：
10.1093/ajcn/80.4.903
复制
发表时间：
2004-10-01
影响因子：
7.1
通讯作者：
Black, RE
中科院分区：
文献类型：
--
作者：
Black, MM;Baqui, AH;Black, RE
背景：铁和锌缺乏症在低收入国家的婴儿期很普遍。目的：目的是检查每周补充铁、锌、铁+锌或 16 种维生素和矿物质的微量营养素混合物 (MM) 是否会改变婴儿的发育和行为。设计：参与者是来自孟加拉国农村地区的 221 名存在微量营养素缺乏风险的婴儿。使用贝利婴儿发育量表 II 和家庭环境观察测量 (HOME) 量表评估 6 个月和 12 个月大的发育和行为。在这项双盲试验中，婴儿被随机分配到 5 种治疗条件中的一种：铁（20 毫克）、锌（20 毫克）、铁+锌、MM（16 种维生素和矿物质，包括铁和锌）或核黄素，从 6 个月到 12 个月每周一次。通过多变量分析来检查每个补充组的发育和行为变化，并控制母亲教育、HOME 评分、母乳喂养月数、贫血、6 个月时的生长情况以及 6 至 12 个月时的生长变化。结果：铁和锌一起服用以及与其他微量营养素一起服用对婴儿运动发育有有益的影响。单独和联合施用铁和锌对定向参与都有有益的影响。三分之二的婴儿患有轻度贫血，没有观察到治疗对血红蛋白浓度的影响，并且血红蛋白与发育或行为指标无关。结论：每周补充铁和锌对运动发育和定向参与的有益影响表明，同时服用这些矿物质对婴儿有益。
Background: Iron and zinc deficiency are prevalent during infancy in low-income countries.Objectives: The objectives were to examine whether a weekly supplement of iron, zinc, iron+zinc, or a micronutrient mix (MM) of 16 vitamins and minerals would alter infant development and behavior.Design: The participants were 221 infants from rural Bangladesh at risk of micronutrient deficiencies. Development and behavior were evaluated at 6 and 12 mo of age by using the Bayley Scales of Infant Development II and the Home Observation Measurement of Environment (HOME) scale. In this double-blind trial, the infants were randomly assigned to 1 of 5 treatment conditions: iron (20 mg), zinc (20 mg), iron+zinc, MM (16 vitamins and minerals, including iron and zinc), or riboflavin weekly from 6 to 12 mo. Multivariate analyses were conducted to examine,the change in development and behavior for each supplementation group, with control for maternal education, HOME score, months breastfed, anemia, growth at 6 mo, and change in growth from 6 to 12 mo.Results: Iron and zinc administered together and with other micro-nutrients had a beneficial effect on infant motor development. Iron and zinc administered individually and in combination had a beneficial effect on orientation-engagement. Two-thirds of the infants were mildly anemic, no treatment effects on hemoglobin concentration were observed, and hemoglobin was not associated with measures of development or behavior.Conclusion: The beneficial effects of weekly iron and zinc supplementation on motor development and orientation-engagement suggest that infants benefit from these minerals when administered together.