Cloning of the human SIX1 gene and its assignment to chromosome 14
Cloning of the human SIX1 gene and its assignment to chromosome 14
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DOI：
10.1006/geno.1996.0172
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发表时间：
1996-04-01
期刊：
影响因子：
4.4
通讯作者：
Johnson, KJ
中科院分区：
文献类型：
--
作者：
Boucher, CA;Carey, N;Johnson, KJ
最近报道的小鼠同源盒基因SIX1和SIX2在四肢肌腱发育过程中表达，也分别在骨骼肌和平滑肌中表达。我们克隆了一个人SIX1基因的序列，Northern blotting表明它在成人骨骼肌中表达。SIX1和SIX1的cDNA序列和预测的蛋白质序列高度同源，预测的氨基酸序列有98%的相似性。SIX1通过啮齿动物/人体细胞杂交小组被定位在人类14号染色体上。(C)1996年学术出版社。
The recently described murine homeobox genes, Six1 and Six2, which are expressed during development in limb tendons, have also been shown to be expressed in skeletal and smooth muscle, respectively, We have cloned and sequenced a human SIX1 cDNA and shown by Northern blotting that it is expressed in adult skeletal muscle. The cDNA sequence and predicted protein sequence of SIX1 and Six1 are highly homologous, with 98% similarity over the entire predicted amino acid sequence, SIX1 was mapped to human chromosome 14 using a rodent/human somatic cell hybrid panel. (C) 1996 Academic Press, Inc.