Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis.
Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis.
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DOI：
10.1038/s41598-017-06378-7
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发表时间：
2017-07-20
影响因子：
4.6
通讯作者：
Zhang Q
中科院分区：
文献类型：
--
作者：
Dong T;Liu Z;Xuan Q;Wang Z;Ma W;Zhang Q
三阴性乳腺癌临床上治疗方法有限，且容易进展至脑部形成转移病灶，演变成晚期。由于原发癌和脑转移瘤均具有较高的糖酵解水平，因此我们推测催化糖酵解最后一步的乳酸脱氢酶（LDH）可能是乳腺癌脑转移的预测因子和治疗靶点。因此，采用免疫组化方法检测119例三阴性乳腺癌组织中LDH-A的表达情况，并测定血清LDH水平。我们的结果显示肿瘤内LDH-A的表达显着高于匹配的正常组织。肿瘤LDH-A表达、血清LDH状态以及血清LDH状态斜率与三阴性乳腺癌脑转移和无脑转移生存密切相关。这项研究表明肿瘤 LDH 和血清 LDH 状态是三阴性乳腺癌脑转移的两个预测因子。
There are limited therapeutic methods for triple negative breast cancer in the clinic, which is easy to progress into the brain to form metastatic lesions and evolve into the terminal stage. Because both the primary cancer and the brain metastasis have high glycolysis, we hypothesize that lactate dehydrogenase (LDH), which catalyzes the final step of glycolysis, may be a predictor, as well as a treatment target, for breast cancer brain metastasis. Therefore, the expression of LDH-A was detected on 119 triple negative breast cancer tissues with immunohistochemistry, and the serum LDH levels were also measured. Our results showed that the LDH-A expression inside the tumor was significantly higher than the matched normal tissues. Tumor LDH-A expression, serum LDH status, and the slope of serum LDH status were closely associated with triple negative breast cancer brain metastasis and brain metastasis free survival. This study indicates that tumor LDH and serum LDH status are two predictors for triple negative breast cancer brain metastasis.
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影响因子：
--
作者：
Arora R;Schmitt D;Karanam B;Tan M;Yates C;Dean-Colomb W
通讯作者：
Dean-Colomb W
FOXM1 通过 LDHA 表达的反式激活促进瓦尔堡效应和胰腺癌进展。
DOI：
10.1158/1078-0432.ccr-13-2407
发表时间：
2014-05-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Cui J;Shi M;Xie D;Wei D;Jia Z;Zheng S;Gao Y;Huang S;Xie K
通讯作者：
Xie K
胃癌的蛋白质组学和代谢组学联合分析揭示了葡萄糖代谢的特征性失调
影响因子：
7
作者：
Cai, Zhen;Zhao, Jiang-Sha;Xie, Dong
通讯作者：
Xie, Dong
DOI：
10.1016/0021-9681(86)90038-x
发表时间：
1986-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
DEYO, RA;CENTOR, RM
通讯作者：
CENTOR, RM
影响因子：
3.7
作者：
Kolev, Yanislav;Uetake, Hiroyuki;Sugihara, Kenichi
通讯作者：
Sugihara, Kenichi