Body mass index modulates the relationship of sugar-sweetened beverage intake with serum urate concentrations and gout.
Body mass index modulates the relationship of sugar-sweetened beverage intake with serum urate concentrations and gout.
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DOI：
10.1186/s13075-015-0781-4
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发表时间：
2015-09-22
影响因子：
4.9
通讯作者：
Merriman TR
中科院分区：
文献类型：
--
作者：
Dalbeth N;Phipps-Green A;House ME;Gamble GD;Horne A;Stamp LK;Merriman TR
含糖饮料（SSB）摄入量和体重指数（BMI）均与血清尿酸盐浓度升高和痛风风险相关。本研究的目的是确定SSB摄入量与血清尿酸盐和痛风的关系是否受到BMI的调节。在一项大型横断面人群研究中分析了长期摄入SSB对血清尿酸盐和痛风状态的影响。在一项短期干预研究中，研究了急性果糖负荷对血清尿酸盐和尿酸排泄分数（FEUA）的影响，持续时间超过180分钟。在所有分析中，比较了BMI <25 mg/kg 2（低BMI）和≥25 mg/kg 2（高BMI）患者的反应。在血清尿酸盐分析中（n = 12，870），高BMI组中长期摄入SSB与血清尿酸盐升高相关，但低BMI组中与之无关（P差异= 3.6 × 10−3）。在痛风分析中（n = 2578），慢性高SSB摄入与高BMI组的痛风相关，但与低BMI组无关（P差异= 0.012）。在急性果糖负荷研究（n = 76）中，高BMI组在基线和整个观察期间血清尿酸升高（PBMI组<0.0001），但两个BMI组对果糖负荷的急性血清尿酸升高相似（P相互作用= 0.99）。两个BMI组之间的基线FEUA相似。然而，在果糖负荷后，BMI组的FEUA反应不同（P相互作用<0.0001），低BMI组在120分钟和180分钟时FEUA增加，而高BMI组在60分钟时FEUA减少。这些数据表明，BMI影响血清尿酸盐和痛风的风险，以响应慢性SSB的摄入，和肾小管尿酸处理，以响应急性果糖负荷。除了许多其他健康益处外，避免SSB对超重/肥胖者尤其重要，以预防高尿酸血症和降低痛风风险。澳大利亚临床试验注册中心ACTRN 12610001036000。2010年11月24日注册。
Both sugar-sweetened beverage (SSB) intake and body mass index (BMI) are associated with elevated serum urate concentrations and gout risk. The aim of this study was to determine whether the associations of SSB intake with serum urate and gout are moderated by BMI. The effects of chronic SSB intake on serum urate and gout status were analysed in a large cross-sectional population study. The effects of an acute fructose load on serum urate and fractional excretion of uric acid (FEUA) were examined over 180 minutes in a short-term intervention study. In all analyses, the responses were compared in those with BMI <25 mg/kg2 (low BMI) and ≥25 mg/kg2 (high BMI). In the serum urate analysis (n = 12,870), chronic SSB intake was associated with increased serum urate in the high BMI group, but not in the low BMI group (Pdifference = 3.6 × 10−3). In the gout analysis (n = 2578), chronic high SSB intake was associated with gout in the high BMI group, but not in the low BMI group (Pdifference = 0.012). In the acute fructose loading study (n = 76), serum urate was increased in the high BMI group at baseline and throughout the observation period (PBMI group <0.0001), but there were similar acute serum urate increases in both BMI groups in response to the fructose load (Pinteraction = 0.99). The baseline FEUA was similar between the two BMI groups. However, following the fructose load, FEUA responses in the BMI groups differed (Pinteraction <0.0001), with increased FEUA at 120 minutes and 180 minutes in the low BMI group and reduced FEUA at 60 minutes in the high BMI group. These data suggest that BMI influences serum urate and gout risk in response to chronic SSB intake, and renal tubular uric acid handling in response to an acute fructose load. In addition to many other health benefits, avoidance of SSBs may be particularly important in those with overweight/obesity to prevent hyperuricaemia and reduce gout risk. Australian Clinical Trials Registry ACTRN12610001036000. Registered 24 November 2010.