Bcl-2 and the ICE family of apoptotic regulators: Making a connection
Bcl-2 and the ICE family of apoptotic regulators: Making a connection
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DOI：
10.1016/s0959-437x(97)80109-8
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发表时间：
1997-02-01
影响因子：
4
通讯作者：
White, E
中科院分区：
文献类型：
--
作者：
Rao, L;White, E
细胞凋亡是一种通过基因编程消除细胞以应对各种刺激的机制，它提供了对癌症和病毒感染的保护，并维持了生物体内的动态平衡。在不同的脊椎动物、无脊椎动物和病毒系统中，已经出现了两类分子，即Bcl2调节蛋白家族和ICE蛋白酶家族，它们被用来阐明导致细胞凋亡的途径。然而，这两个不同的凋亡调控家族之间的联系还没有令人信服地建立起来。在回顾与Bcl2和ICE相关的蛋白质家族的最新进展时，可以解决这两类蛋白质之间的功能关系的问题。
Apoptosis, a genetically programmed mechanism of eliminating cells in response to a variety of stimuli, provides protection against cancer and viral infections as well as maintenance of homeostasis in living organisms. Two classes of molecules, the Bcl-2 family of regulators and the ICE family of proteases, have emerged from different vertebrate, invertebrate and viral systems that have been used to elucidate the pathways leading to apoptosis. However, no connection between these two disparate families of apoptotic regulators has been convincingly established. In reviewing the recent advances pertaining to the Bcl-2 and ICE-related protein families, one can address the question of a functional relationship between the two classes of proteins.