Innate Defense against Fungal Pathogens.
Innate Defense against Fungal Pathogens.
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对真菌病原体的先天防御。
DOI：
10.1101/cshperspect.a019620
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发表时间：
2014-11-10
影响因子：
5.4
通讯作者：
Brown GD
中科院分区：
文献类型：
--
作者：
Drummond RA;Gaffen SL;Hise AG;Brown GD
近年来，人类真菌感染一直在上升，事实证明，由于缺乏诊断、有效的抗真菌治疗和疫苗，人类真菌感染越来越难以治疗。大多数致病真菌不会致病，除非免疫稳态受到干扰，这可能是由现代医学干预、疾病诱导的免疫抑制和自然发生的人类突变引起的。天然免疫系统通过表达广泛的模式识别受体(PRRs)的特化细胞，很好地识别和摧毁真菌病原体。这篇综述将概述有效的抗真菌免疫所需的细胞和PRRs，特别是主要的抗真菌细胞因子IL-17和最近表征的抗真菌炎症体。
Human fungal infections have been on the rise in recent years and proved increasingly difficult to treat as a result of the lack of diagnostics, effective antifungal therapies, and vaccines. Most pathogenic fungi do not cause disease unless there is a disturbance in immune homeostasis, which can be caused by modem medical interventions, disease induced immunosuppression, and naturally occurring human mutations. The innate im mune system is weII equipped to recognize and destroy pathogeni cf ungi through speciaIized cells expressing a broad range of pattern recognition receptors (PRRs). This review will outline the cells and PRRs required for effective antifungal immunity, with a special focus on the major antifungal cytokine IL-17 and recently characterized antifungal inflammasomes.