DIABETES MELLITUS : ENQUIRY INTO ITS MEDICAL ASPECTS AND BIOENGINEERING OF ITS MONITORING AND REGULATION
DIABETES MELLITUS : ENQUIRY INTO ITS MEDICAL ASPECTS AND BIOENGINEERING OF ITS MONITORING AND REGULATION
复制标题
糖尿病：对其医学方面及其监测和调节的生物工程的探究
DOI：
10.1142/s0219519412004417
复制
发表时间：
2012
影响因子：
0.8
通讯作者：
Jasjit S Suri
中科院分区：
文献类型：
--
作者：
U Rajendra Acharya;Dhanjoo N Ghista;Myagmarbayar Nergui Subhagata Chattopadhyay;E Y K NG;Vinitha Sree S;Jasper W K Tong;Jen Hong Tan;Loh Kah Meng;Jasjit S Suri
糖尿病（DM）或高血糖症（更广义的术语，高血糖）是一种代谢紊乱，目前在世界人口中非常普遍。人们摄入的大部分食物都转化为葡萄糖，葡萄糖通过吸收-同化机制进入血液。作为一个自然过程，我们体内的细胞利用葡萄糖来生长和提供能量。葡萄糖平衡是由一种叫做胰岛素的激素维持的，胰岛素是由胰腺的β细胞分泌的。在DM发生的背景下的假设是（i）没有产生和分泌足够的胰岛素，导致血液中葡萄糖水平增加，或（ii）胰岛素对葡萄糖不敏感，或（iii）胰岛素是非靶向的等。如果DM随着时间的推移保持不受控制，它会导致对许多身体系统的严重损害，特别是神经和血管。本文从多个角度探讨糖尿病：（i）糖尿病作为一种疾病，其并发症，原因，诊断测试和治疗;（ii）视网膜和足底图像的分析，以表征糖尿病并发症;（iii）如何分析心率变异性信号可以描述糖尿病;（iv）葡萄糖-胰岛素调节系统的生物医学工程及其在口服葡萄糖耐量试验数据建模中的应用，检测糖尿病以及有患糖尿病风险的人;（v）应用葡萄糖-胰岛素调节系统来配制用于控制血糖的胰岛素输送系统。
Diabetes mellitus (DM) or hyperglycemia (in a more generalized term, high blood sugar) is a metabolic disorder that is now highly prevalent in the world population. Most of the food that people consume is converted into glucose, which enters the bloodstream following absorption–assimilation mechanisms. As a natural process, cells in our body utilize glucose for growth and energy. The glucose balance is maintained by a hormone called insulin that is secreted by the beta cells of pancreas. Hypotheses at the backdrop of DM occurrence are either (i) enough insulin is not produced and secreted resulting in increased level of glucose in blood, or (ii) insulin is insensitive to glucose, or (iii) insulin is non-targeted etc. If DM remains uncontrolled over time, it leads to serious damage to many of the body's systems, especially the nerves and blood vessels. This paper develops an enquiry into diabetes from many angles: (i) Diabetes as a disorder, its complications, causes, diagnostic tests, and treatment; (ii) Analysis of retinal and plantar images to characterize diabetes complications; (iii) How analysis of heart rate variability signals can depict diabetes; (iv) Biomedical engineering of the glucose–insulin regulatory system, and its employment in the modeling of the oral glucose tolerance test data, to detect diabetes as well as persons at risk of being diabetic; (v) Application of the glucose–insulin regulatory system to formulate an insulin delivery system for controlling blood sugar.