Photographic Assessment of Baseline Fundus Morphologic Features in the Comparison of Age-related Macular Degeneration Treatments Trials
Photographic Assessment of Baseline Fundus Morphologic Features in the Comparison of Age-related Macular Degeneration Treatments Trials
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DOI：
10.1016/j.ophtha.2012.02.013
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发表时间：
2012-08-01
期刊：
影响因子：
13.7
通讯作者：
Martin, Daniel F.
中科院分区：
文献类型：
--
作者：
Grunwald, Juan E.;Daniel, Ebenezer;Martin, Daniel F.
目的：目的：描述在视网膜相关黄斑变性治疗比较试验（CATT）中用于评估彩色照相和荧光素血管造影（FA）基线眼底特征的方法，并描述这些特征与视力之间的关系。设计：随机、盲法、多中心试验。参与者：本研究包括1185名CATT研究的参与者。CATT研究参与者的基线立体彩色眼底照片和FA在中央眼底照片阅读中心由盲读者进行评估。重复评估随机样本的照片进行评估，以评估内年级和年级间的协议。使用方差和相关系数分析的病变特征与基线视力进行了评估。主要结果测量：Intragrader和intergrader再现性，视力，和病变characteristics.Results：Intragrader和intergrader再现性显示协议范围从75%到100%和加权kappa值范围从0.48到1.0的定性determinations。定量测量脉络膜新生血管（CNV）面积和CNV病变总面积的组内相关系数为0.96 ~ 0.97。平均视力随中心凹病理特征的类型而变化：仅液体组64.5个字母（标准误0.7个字母），CNV组59.0个字母（标准误0.5个字母），出血组58.7个字母（标准误1.3个字母）（P
Objective: To describe the methods used for assessment of baseline fundus characteristics from color photography and fluorescein angiography (FA) in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) and to describe the relationship between these characteristics and visual acuity.Design: Randomized, masked, multicenter trial.Participants: This investigation included 1185 participants of the CATT study.Methods: Baseline stereoscopic color fundus photographs and FAs of participants in the CATT study were assessed at a central fundus photograph reading center by masked readers. Replicate assessments of random samples of photographs were performed to assess intragrader and intergrader agreements. The association of the lesion characteristics with baseline visual acuity was assessed using analyses of variance and correlation coefficients.Main Outcome Measures: Intragrader and intergrader reproducibility, visual acuity, and lesion characteristics.Results: Intragrader and intergrader reproducibility showed agreements ranging from 75% to 100% and weighted kappa values ranging from 0.48 to 1.0 for qualitative determinations. The intraclass correlation coefficients were 0.96 to 0.97 for quantitative measurements of choroidal neovascularization (CNV) area and total area of CNV lesion. The mean visual acuity varied by the type of pathologic features in the foveal center: 64.5 letters (standard error, 0.7 letters) for fluid only, 59.0 letters (standard error, 0.5 letters) for CNV, and 58.7 letters (standard error, 1.3 letters) for hemorrhage (P