Recent advances in chemoprevention of cancer
Recent advances in chemoprevention of cancer
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DOI：
10.1126/science.278.5340.1073
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发表时间：
1997-11-07
期刊：
影响因子：
56.9
通讯作者：
Sporn, MB
中科院分区：
文献类型：
--
作者：
Hong, WK;Sporn, MB
化学预防是使用药物或天然药物，通过阻断引发癌变的 DNA 损伤，或通过阻止或逆转已经发生此类损伤的癌前细胞的进展来抑制侵袭性癌症的发展。我们对致癌机制理解的最新进展导致了新药的合成，这些新药可以通过选择性作用于特定分子靶点（例如雌激素、雄激素和类维生素A受体或诱导型环氧合酶）来抑制实验动物肿瘤的发展。其中几种药物（包括他莫昔芬、13-顺式视黄酸、棕榈酸视黄酯和无环视黄酸）在临床上可有效预防癌症的发展，特别是对于手术切除初始肿瘤后发生第二原发肿瘤的高风险患者。
Chemoprevention is the use of pharmacologic or natural agents that inhibit the development of invasive cancer either by blocking the DNA damage that initiates carcinogenesis or by arresting or reversing the progression of premalignant cells in which such damage has already occurred. Recent advances in our understanding of the mechanisms of carcinogenesis have led to the synthesis of new drugs that can inhibit tumor development in experimental animals by selective action on specific molecular targets, such as the estrogen, androgen, and retinoid receptors or inducible cyclooxygenase. Several of these agents (including tamoxifen, 13-cis-retinoic acid, retinyl palmitate, and an acyclic retinoid) are clinically effective in preventing the development of cancer, particularly in patients who are at high risk for developing second primary tumors after surgical removal of the initial tumor.