MiR-378a-3p enhances adipogenesis by targeting mitogen-activated protein kinase 1
MiR-378a-3p enhances adipogenesis by targeting mitogen-activated protein kinase 1
复制标题
MiR-378a-3p 通过靶向丝裂原激活蛋白激酶 1 增强脂肪生成
DOI：
10.1016/j.bbrc.2014.12.055
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发表时间：
2015-01-30
影响因子：
3.1
通讯作者：
Zhang, Yaou
中科院分区：
文献类型：
--
作者：
Huang, Nunu;Wang, Jiu;Zhang, Yaou
Previous studies showed that miR-378a plays important roles in adipogenesis and obesity; however, the precise mechanisms of action remain unknown. Here, we found that miR-378a-3p expression is up-regulated in adipose tissues of high fat diet-induced obese mice, as well as during the differentiation of 3T3-L1 preadipocytes. Mir-378a-3p induced adipogenesis by targeting mitogen-activated protein kinase 1 (MAPK1). Overexpression of miR-378a-3p or silencing MAPK1 reduced MAPK1 expression and enhanced adipogenesis, whereas blockage of endogenous miR-378a-3p had the opposite effect, suggesting that miR-378a-3p promotes the adipogenesis of 3T3-L1 cells by targeting MAPK1. (C) 2014 Elsevier Inc. All rights reserved.
