Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.
Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.
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DOI：
10.1080/21541248.2016.1218407
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发表时间：
2018-05-04
期刊：
影响因子：
--
通讯作者：
Olson MF
中科院分区：
文献类型：
--
作者：
Olson MF
Rho GT3家族的20个成员是多种生物活性的关键调节剂。作为对激活的响应，它们通过下游效应蛋白发出信号以诱导肌动球蛋白细胞骨架组织的动态改变。在这篇综述中，翻译后修饰，在人类病理条件下确定的失调机制，以及Rho GTPases可能被靶向化疗的方式将进行讨论。
The 20 members of the Rho GTPase family are key regulators of a wide-variety of biological activities. In response to activation, they signal via downstream effector proteins to induce dynamic alterations in the organization of the actomyosin cytoskeleton. In this review, post-translational modifications, mechanisms of dysregulation identified in human pathological conditions, and the ways that Rho GTPases might be targeted for chemotherapy will be discussed.