Accumulation of memory T cells from childhood to old age:: Central and effector memory cells in CD4+ versus effector memory and terminally differentiated memory cells in CD8+ compartment
Accumulation of memory T cells from childhood to old age:: Central and effector memory cells in CD4+ versus effector memory and terminally differentiated memory cells in CD8+ compartment
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DOI：
10.1016/j.mad.2005.11.001
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发表时间：
2006-03-01
影响因子：
5.3
通讯作者：
Labalette, M
中科院分区：
文献类型：
--
作者：
Saule, P;Trauet, J;Labalette, M
记忆T细胞可以分为中央记忆（T-CM，CD 45 RA（neg）CCR 7（+））、效应记忆（T-EM，CD 45 RA（neg）CCR 7（neg））和具有不同归巢和效应能力的终末分化细胞（T-TD，CD 45 RA（+）CCR 7（neg））。在101例年龄在5 - 96岁的健康受试者中，循环CD 4+和CD 8 + T细胞群之间存在明显的动态变化。初始CD 4+和CD 8 + T细胞随年龄线性下降，CD 8+下降速度快两倍。在CD 4（+）和CD 8+库中，记忆细胞的平均年龄分别为37.4岁和29.5岁。CD 4 + T-CM和T-EM细胞呈正相关，随年龄增长呈线性增长，而CD 4 + TTD仍很少见。CD 8 + T-EM和TTD随年龄增长呈线性增加，而T-CM仅略有增加，并且每个记忆子集与其他两个子集呈负相关。几乎所有的CD 8 + T-TD和一些CD 8 + T-EM都失去了CD 28的表达。尽管动力学不同，但每个单独的CD 4+幼稚和记忆亚群与同义的CD 8+亚群相关。年龄≥ 65岁的受试者中，有一半的受试者的特征是CD 8+初始细胞计数极度减少，而CD 8 + TTD细胞计数增加，这可能表明从该年龄开始免疫系统衰退加速。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Memory T cells can be classified as central memory (T-CM, CD45RA(neg)CCR7(+)), effector memory (T-EM, CD45RA(neg)CCR7(neg)), and terminally differentiated cells (T-TD, CD45RA(+)CCR7(neg)) with different homing and effector capacities. In 101 healthy subjects aged from 5 to 96 years, distinct dynamics were evidenced between circulating CD4+ and CD8+ T cell populations. Naive CD4+ and CD8+ T cells decreased linearly with age, CD8+ twice more rapidly. Memory cells outnumbered naive cells on average at 37.4 in the CD4(+) and 29.5 years of age in the CD8+ pool. CD4+ T-CM and T-EM cells were positively correlated and increased linearly at a similar rate with age, while CD4+ TTD remained rare. CD8+ T-EM and TTD accumulated linearly with age, while T-CM increased only slightly, and each memory subset was negatively correlated to the two others. Almost all CD8+ T-TD and some CD8+ T-EM had lost CD28 expression. Despite different dynamics, each individual CD4+ naive and memory subset was correlated to the synonymous CD8+ subset. Half of the subjects aged 65 years or older were characterized by extremely reduced CD8+ naive and increased CD8+ TTD cell counts, which could indicate an acceleration of the decay of the immune system from this age onward. (c) 2005 Elsevier Ireland Ltd. All rights reserved.