Antagonistic effect of theophylline on the adenosine-induced decreased in renin release.
Antagonistic effect of theophylline on the adenosine-induced decreased in renin release.
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茶碱对腺苷引起的肾素释放减少有拮抗作用。
DOI：
10.1152/ajprenal.1984.247.2.f246
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Spielman,WS
中科院分区：
文献类型：
--
作者：
Spielman,WS
本文研究了茶碱对腺苷引起的麻醉犬肾素释放减少的影响。腺苷抑制肾素释放，减少肾小球滤过率和部分钠排泄，降低肾淋巴中血管紧张素II的浓度。茶碱(5 mumol/min)对肾小球滤过率(GFR)和肾小球滤过率(RBF)无明显影响，但可显著增加肾素的释放和钠的排泄。肾内注射腺苷(3×10~(-7)m o l/m in)对肾小球滤过率(GFR)和肾小球滤过率(RBF)无明显影响，但显著减少钠排泄和肾素释放。第二组犬在茶碱(5×10(-6)mol/min)输注的同时，以较小剂量(3×10(-8)mol/min)输注腺苷。除部分钠排泄外，茶碱可有效拮抗腺苷的所有作用。5×10~(-6)mol/min的茶碱可刺激肾素释放，并有效拮抗腺苷的肾脏效应，但对肾皮质cAMP无明显影响。此外，皮质cAMP没有变化，直到茶碱增加50倍以上的剂量有效地拮抗腺苷。这些发现表明，茶碱在对皮质cAMP没有影响的浓度下，可以拮抗腺苷对肾素释放的影响。这一结果也与茶碱刺激肾素释放的观点一致，该机制不是通过对cAMP的作用实现的。
The action of theophylline on the adenosine-induced decrease in renin release was studied in anesthetized dogs. Adenosine inhibited renin release, decreased GFR and fractional sodium excretion, and decreased the concentration of angiotensin II in the renal lymph. Theophylline (5 mumol/min intrarenally) had no significant effect on GFR or RBF yet produced a significant increase in the release of renin and the fractional excretion of sodium. The intrarenal infusion of adenosine (3 X 10(-7) mol/min) during theophylline infusion produced no effect on GFR or RBF, but fractional sodium excretion and renin release were significantly decreased. Adenosine was infused at a lower dose (3 X 10(-8) mol/min) during theophylline (5 X 10(-6) mol/min) infusion in a second group of dogs. With the exception of fractional sodium excretion, all effects of adenosine were effectively antagonized by theophylline. Theophylline at 5 X 10(-6) mol/min, which stimulates renin release and effectively antagonizes the renal effects of adenosine, had no detectable effect on cAMP measured in renal cortex. Furthermore, no change in cortical cAMP was observed until theophylline was increased 50-fold over the dose effective in antagonizing adenosine. These findings demonstrate that theophylline, at concentrations having no effect on cortical cAMP, antagonizes the effect of adenosine on renin release. The results are also consistent with the view that theophylline stimulates renin release by a mechanism other than its action on cAMP.