MODULATION OF POSTURAL TREMORS AT THE WRIST BY SUPRAMAXIMAL ELECTRICAL MEDIAN NERVE SHOCKS IN ESSENTIAL TREMOR, PARKINSONS-DISEASE AND NORMAL SUBJECTS MIMICKING TREMOR
MODULATION OF POSTURAL TREMORS AT THE WRIST BY SUPRAMAXIMAL ELECTRICAL MEDIAN NERVE SHOCKS IN ESSENTIAL TREMOR, PARKINSONS-DISEASE AND NORMAL SUBJECTS MIMICKING TREMOR
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DOI：
10.1136/jnnp.56.10.1085
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发表时间：
1993-10-01
影响因子：
11
通讯作者：
MARSDEN, CD
中科院分区：
文献类型：
--
作者：
BRITTON, TC;THOMPSON, PD;MARSDEN, CD
在遗传性特发性震颤（n = 10）和帕金森病（n = 9）患者和模仿腕部震颤的正常受试者（n = 8）中检查姿势性腕部震颤对超大正中神经刺激的反应。所有三组中持续震颤的平均频率相同。超最大外周神经电击抑制，然后同步的节律性肌电图（EMG）活动的所有类型的震颤。抑制持续时间为90 ~ 210 ms，与持续震颤频率成反比。有没有显着差异的平均持续时间的抑制或刺激后的第一个峰值的时间，平均整流EMG记录之间的三组。在何种程度上，超大外周神经电击可以调制的前臂屈肌肌的节律性肌电图爆发的时间也定量推导出一个重置指数。三组的平均复位指数无显著差异，这些结果表明，这些研究不能用于区分常见的原因姿势性腕关节震颤。
The response of postural wrist tremors to supramaximal median nerve stimulation was examined in patients with hereditary essential tremor (n = 10) and Parkinson's disease (n = 9), and in normal subjects mimicking wrist tremor (n = 8). The average frequency of on-going tremor was the same in all three groups. Supramaximal peripheral nerve shocks inhibited and then synchronised the rhythmic electromyographic (EMG) activity of all types of tremor. The duration of inhibition ranged from 90 to 210ms, varying inversely with the frequency of on-going tremor. There was no significant difference in mean duration of inhibition or in the timing of the first peak after stimulation on the average rectified EMG records between the three groups. The degree to which supramaximal peripheral nerve shocks could modulate the timing of rhythmic EMG bursts in the forearm flexor muscles was also quantified by deriving a resetting index. No significant difference in mean resetting index of the three groups was found. These results suggest that such studies cannot be used to differentiate between the common causes of postural wrist tremors.