What is worse for asthma control and quality of life - Depressive disorders, anxiety disorders, or both?
What is worse for asthma control and quality of life - Depressive disorders, anxiety disorders, or both?
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DOI：
10.1378/chest.130.4.1039
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发表时间：
2006-10-01
期刊：
影响因子：
9.6
通讯作者：
Labrecque, Manon
中科院分区：
文献类型：
--
作者：
Lavoie, Kim L.;Bacon, Simon L.;Labrecque, Manon
背景：哮喘的高负担似乎与哮喘控制不良有关。虽然以前的研究已经报道了抑郁症（DD）和焦虑症（AD）与哮喘控制和生活质量较差之间的相关性，但这些疾病对哮喘控制和生活质量的相对影响尚未探讨。本研究评估了相对的影响，有DD和/或AD哮喘控制和quality of life.Method：504个连续的成年人与确认，医生诊断的哮喘进行了简短的，结构化的精神访谈，使用初级保健评估的精神疾病。使用哮喘控制问卷（ACQ）和哮喘生活质量问卷（AQLQ）评估哮喘控制和哮喘相关生活质量。所有患者进行标准肺功能测定。结果：31%的患者（n = 157）符合一个或多个精神疾病的诊断标准（8%的DD只有，12%的AD只有，和11%的两者）。分析显示，DD对ACQ总分有独立影响（p < 0.01），DD和AD对AQLQ总分和所有四个AQLQ分量表有独立影响（p < 0.05）。没有交互作用effects.Conclusions：结果表明，DD和AD与哮喘相关的生活质量较差，但只有DD与哮喘控制较差。有趣的是，同时患有DD和AD并没有增加哮喘控制或生活质量恶化的风险。在评估哮喘控制水平和生活质量时，医生可能需要考虑消极情绪状态的不同影响。
Background: The high burden of asthma appears to be related to poor asthma control. Although previous studies have reported associations between depressive disorders (DDs) and anxiety disorders (ADs) and worse asthma control and quality of life, the relative impact of these disorders on asthma control and quality of life has not been explored. This study evaluated the relative impact of having a DD and/or AD on asthma control and quality of life.Method: Five hundred four consecutive adults with confirmed, physician-diagnosed asthma underwent a brief, structured psychiatric interview using the Primary Care Evaluation of Mental Disorders. Asthma control and asthma-related quality of life were assessed using the Asthma Control Questionnaire (ACQ) and the Asthma Quality of Life Questionnaire (AQLQ). All patients underwent standard spirometry.Results: Thirty-one percent of patients (n = 157) met the diagnostic criteria for one or more psychiatric disorders (8% had DD only, 12% had AD only, and 11% had both). Analyses revealed independent effects for DDs on total ACQ scores (p < 0.01), and for DDs and ADs on total AQLQ scores and all four AQLQ subscales (p < 0.05). There were no interaction effects.Conclusions: Results suggest that DDs and ADs are associated with worse asthma-related quality of life, but only DDs are associated with worse asthma control. Interestingly, having both a DD and an AD did not confer additional risk for worse asthma control or quality of life. Physicians may want to consider the differential impact of negative mood states when assessing levels of asthma control and quality of life.