Compartmentalization of HIV-1 between breast milk and blood of HIV-infected mothers
Compartmentalization of HIV-1 between breast milk and blood of HIV-infected mothers
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DOI：
10.1006/viro.2002.1537
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发表时间：
2002-08-15
期刊：
影响因子：
3.7
通讯作者：
Hocini, H
中科院分区：
文献类型：
--
作者：
Becquart, P;Chomont, N;Hocini, H
在三名HIV-1感染母亲中比较了母乳和外周血中的HIV-1变异。DNA和RNA env C2-V3序列的分析表明，HIV变异体在两个区室之间存在差异分布。母乳中发现的主要前病毒变体对应于两个母亲血液中的次要变体。在第三位母亲中，在母乳中检测到的主要前病毒变体在HIV-1血液人群中不存在。母乳中的主要RNA变体在两名母亲的血液中没有表现出来。然而，第三位母亲的母乳和血液中的主要RNA变体是相同的。出乎意料的是，三位母亲母乳中游离病毒变体的模式与前病毒形式不一致，表明游离病毒并非来自母乳中受感染的细胞。外周血和母乳之间的HIV-1区室化的观察强调，出生后的艾滋病毒传播发生的变异，可能无法预测从分析循环病毒种群。(C)2002 Elsevier Science（美国）。
HIV-1 variants in breast milk and peripheral blood have been compared in three HIV-1 infected mothers. Analysis of DNA and RNA env C2-V3 sequences showed a differential distribution of HIV variants between the two compartments. The major provirus variant found in breast milk corresponds to a minor variant in the blood of two mothers. In the third mother, the predominant proviral variant detected in breast milk was not represented in the HIV-1 blood population. The major RNA variant in breast milk was not represented in the blood of two mothers. The predominant RNA variant in breast milk and blood was however the same for the third mother. Unexpectedly, the pattern of free virus variants in breast milk of three mothers did not correspond to that of the proviral form, suggesting that free viruses do not derive from infected cells in breast milk. The observation of a compartmentalization of HIV-1 between peripheral blood and breast milk emphasizes that postnatal transmission of HIV occurs with variants that may not be predicted from the analysis of circulating viral populations. (C) 2002 Elsevier Science (USA).