A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver:: Inhibition of NF-κB?
A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver:: Inhibition of NF-κB?
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DOI：
10.1016/j.tox.2007.12.008
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发表时间：
2008-04-03
期刊：
影响因子：
4.5
通讯作者：
Wright, M. C.
中科院分区：
文献类型：
--
作者：
Axon, A.;Cowie, D. E.;Wright, M. C.
肝脏容易因接触各种毒素（例如酒精）和病毒（例如Q型肝炎）而受到慢性损伤。肥胖、自身免疫性疾病（例如自身免疫性肝炎）和各种遗传性疾病（例如威尔逊病）也会导致慢性肝损伤。这种损伤导致器官的瘢痕纤维形成、结构破坏和功能损害。最近的研究表明，在PXR和NF-κ B通路之间存在串扰。这种相互作用可以解释PXR激活剂在体外和体内疾病动物模型中抑制肝纤维化的观察结果。本文将重点介绍这两种转录因子及其相互作用。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
The liver is susceptible to chronic damage through exposure to a variety of toxins (e.g. alcohol) and viruses (e.g. hepatitis Q. Obesity, autoimmune diseases (e.g. autoimmune hepatitis) and a variety of genetic diseases (e.g. Wilson's disease) also lead to chronic liver damage. This damage results in scarring fibrogenesis, structural disruption and functional impairment of the organ. Recent work suggests that there is cross-talk between the PXR and NF-kappa B pathways. This cross-talk may explain the observation that PXR activators inhibit liver fibrosis in in vitro and in vivo animal models of the disease. This reveiw will focus on the two transcription factors and their potential interaction. (c) 2007 Elsevier Ireland Ltd. All rights reserved.