Optical imaging of nociception in primary somatosensory cortex of non-human primates.
Optical imaging of nociception in primary somatosensory cortex of non-human primates.
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发表时间：
2008-10
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通讯作者：
Limin Chen;R. Friedman;A. Roe
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作者：
Limin Chen;R. Friedman;A. Roe
虽然在正常人和慢性疼痛患者的功能成像研究中一致报道了疼痛感知过程中初级躯体感觉（SI）皮层的激活，但SI，特别是SI内的子区域，在疼痛感觉方面的处理中的具体作用仍然在很大程度上未知。利用光学成像的内在信号（OIS）和单单位电生理学，我们研究了皮质激活模式内SI皮质（Brodmann区3a，3b和1）和信号幅度的变化，不同强度的非伤害性，热伤害性和机械伤害性刺激的个别远端finerpads在麻醉的松鼠猴。我们已经证明，区域3a和1优先参与伤害性信息的处理，而区域3b和1优先激活非伤害性（触摸）信息的处理。伤害性激活的个人指垫组织地形表明，伤害性地形图存在于3a和1区。在3a、3b和1区，随着机械伤害性刺激强度的增加，信号幅度增强。在区域1内，伤害性反应与非伤害性反应共定位。因此，我们假设伤害性信息在SI皮层内是区域特异性表示的，其中伤害性输入优先表示在区域3a和1中，而非伤害性输入优先表示在区域3b和1中。
While the activation of primary somatosensory (SI) cortex during pain perception is consistently reported in functional imaging studies on normal subjects and chronic pain patients, the specific roles of SI, particularly the subregions within SI, in the processing of sensory aspects of pain are still largely unknown. Using optical imaging of intrinsic signal (OIS) and single unit electrophysiology, we studied cortical activation patterns within SI cortex (among Brodmann areas 3a, 3b and 1) and signal amplitude changes to various intensities of non-nociceptive, thermal nociceptive and mechanical nociceptive stimulation of individual distal finerpads in anesthetized squirrel monkeys. We have demonstrated that areas 3a and 1 are preferentially involved in the processing of nociceptive information while areas 3b and 1 are preferentially activated in the processing of non-nociceptive (touch) information. Nociceptive activations of individual fingerpad were organized topographically suggesting that nociceptive topographic map exits in areas 3a and 1. Signal amplitude was enhanced to increasing intensity of mechanical nociceptive stimuli in areas 3a, 3b and 1. Within area 1, nociceptive response co-localizes with the non-nociceptive response. Therefore, we hypothesize that nocicepitve information is area-specifically represented within SI cortex, in which nociceptive inputs are preferentially represented in areas 3a and 1 while non-nociceptive inputs are preferentially represented in areas 3b and 1.