Internalizing and externalizing disorders as predictors of alcohol use disorder onset during three developmental periods
Internalizing and externalizing disorders as predictors of alcohol use disorder onset during three developmental periods
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DOI：
10.1016/j.drugalcdep.2016.04.021
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发表时间：
2016-07-01
影响因子：
4.2
通讯作者：
Lewinsohn, Peter M.
中科院分区：
文献类型：
--
作者：
Farmer, Richard F.;Gau, Jeff M.;Lewinsohn, Peter M.
背景资料：与未来酒精使用障碍（AUD）风险增加相关的发育途径仍然是一个既有趣又有争议的话题。在这项研究中，内化和外化障碍被评估为指标AUD发作的前瞻性预测因子，分别在三个发展阶段：（13.0-17.9岁），青春期后期（18.0-20.9），以及成年早期（21.0-30.0）.方法：参与者（N = 816）最初是从俄勒冈州西部的九所高中随机挑选的，随后在16岁和18岁之间的四个不同的场合进行了采访。30，在此期间，当前和过去的AUD进行了评估，以及一个完整的范围内的精神疾病与内化和外化psychopathology domains.Results：在调整后的分析，为每三个发展时期的调查，外化域的精神病理学从最近的相邻的发展时期预测AUD发作。远端外化精神病理学也预测了早期成人发病病例中的AUD发病。近端或远端内化的精神病理学，相比之下，没有发现是一个显着的预测AUD发作的调整分析的任何发展periodsexamined.Conclusions：研究结果总体上表明，外化的发展历史是强大的预测AUD发作的年龄范围内的指数发作是最有可能发生的，性别不缓和这种关联。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Background: The developmental pathways associated with an enhanced risk for future alcohol use disorders (AUDs) continue to be a topic of both interest and debate. In this research, internalizing and externalizing disorders were evaluated as prospective predictors of the index AUD episode onset, separately within three developmental periods: early-to-middle adolescence (age 13.0-17.9), late adolescence (18.0-20.9), and early adulthood (21.0-30.0).Methods: Participants (N = 816) were initially randomly selected from nine high schools in western Oregon and subsequently interviewed on four separate occasions between ages 16 and 30, during which current and past AUDs were assessed as well as a full range of psychiatric disorders associated with internalizing and externalizing psychopathology domains.Results: In adjusted analyses for each of the three developmental periods investigated, externalizing domain psychopathology from the most proximal adjoining developmental period predicted AUD onset. Distal externalizing psychopathology also predicted AUD onset among early adult onset cases. Proximal or distal internalizing psychopathology, in comparison, was not found to be a significant predictor of AUD onset in adjusted analyses for any of the developmental periods examined.Conclusions: Findings overall suggest that externalizing developmental histories are robust predictors of AUD onset within the age range during which index episodes are most likely to occur, and that gender does not moderate this association. (C) 2016 Elsevier Ireland Ltd. All rights reserved.