Nuclear Import of Hepatitis B Virus Capsids and Genome.

Nuclear Import of Hepatitis B Virus Capsids and Genome.
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DOI:
10.3390/v9010021
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发表时间:
2017-01-21
期刊:
Viruses
影响因子:
--
通讯作者:
Kann M
Kann M
中科院分区:
其他
文献类型:
--
作者:
Gallucci L;Kann M

文献摘要

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乙型肝炎病毒(HBV)是一种具有DNA基因组的包膜副逆转录病毒,存在于长达36纳米的衣壳中。基因组的复制是通过在细胞核中合成的RNA中间体进行的。因此,病毒必须有办法将其DNA基因组运送到这个隔室中。本文综述了乙型肝炎病毒基因组转运的相关资料,并将这一发现与其他病毒的相关发现联系起来。
Hepatitis B virus (HBV) is an enveloped pararetrovirus with a DNA genome, which is found in an up to 36 nm-measuring capsid. Replication of the genome occurs via an RNA intermediate, which is synthesized in the nucleus. The virus must have thus ways of transporting its DNA genome into this compartment. This review summarizes the data on hepatitis B virus genome transport and correlates the finding to those from other viruses.