Cancer of the vulva
Cancer of the vulva
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DOI：
10.1002/ijgo.12609
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发表时间：
2018-10-01
影响因子：
3.8
通讯作者：
Cuello, Mauricio A.
中科院分区：
文献类型：
--
作者：
Rogers, Linda J.;Cuello, Mauricio A.
外阴癌是一种罕见的妇科恶性肿瘤，主要影响绝经后妇女。没有特异性筛查，降低外阴癌发病率的最有效策略是对与其发展相关的易感性和癌前病变进行适当治疗。虽然外阴癌可能是无症状的，但大多数女性表现为外阴瘙痒或疼痛，或注意到肿块或溃疡。因此，任何可疑的外阴病变应活检，以排除侵犯。一旦建立，最常见的亚型是鳞状细胞癌。外阴癌的治疗主要取决于组织学和手术分期。治疗主要是手术，特别是鳞状细胞癌，虽然同步放化疗是一种有效的选择，特别是对晚期肿瘤。管理应该是个性化的，并在这些肿瘤的治疗经验丰富的癌症中心的多学科团队进行。
Vulvar cancer is an uncommon gynecological malignancy primarily affecting postmenopausal women. There is no specific screening and the most effective strategy to reduce vulvar cancer incidence is the opportune treatment of predisposing and preneoplastic lesions associated with its development. While vulvar cancer may be asymptomatic, most women present with vulvar pruritus or pain, or have noticed a lump or ulcer. Therefore, any suspicious vulvar lesion should be biopsied to exclude invasion. Once established, the most common subtype is squamous cell carcinoma. Treatment of vulvar cancer depends primarily on histology and surgical staging. Treatment is predominantly surgical, particularly for squamous cell carcinoma, although concurrent chemoradiation is an effective alternative, particularly for advanced tumors. Management should be individualized, and carried out by a multidisciplinary team in a cancer center experienced in the treatment of these tumors.