Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models.
Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models.
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DOI：
10.2174/157340211799304761
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发表时间：
2011-12
影响因子：
2.3
通讯作者：
Caron KM
中科院分区：
文献类型：
--
作者：
Karpinich NO;Hoopes SL;Kechele DO;Lenhart PM;Caron KM
肾上腺髓质素是一种高度保守的肽，涉及从妊娠和胚胎发育到肿瘤进展的各种生理过程。这篇综述强调了过去和现在的研究，有助于我们目前的赞赏肾上腺髓质素在正常和疾病条件下发挥的重要作用。我们特别强调肾上腺髓质素在血管内皮细胞中的功能，以及遗传小鼠模型的实验方法如何有助于推动该领域的发展。
Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.