Solving the enigma: Mass spectrometry and small molecule probes to study sphingolipid function
Solving the enigma: Mass spectrometry and small molecule probes to study sphingolipid function
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解开谜团：质谱法和小分子探针研究鞘脂功能
DOI：
10.1016/j.cbpa.2021.05.001
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发表时间：
2021
影响因子：
7.8
通讯作者：
Atilla-Gokcumen, G. Ekin
中科院分区：
文献类型：
--
作者：
Millner, Alec;Atilla-Gokcumen, G. Ekin
鞘脂是高生物活性的脂质。鞘脂代谢产生关键的膜组分（如鞘磷脂）和具有不同生物学功能的多种信号脂质（如神经酰胺、鞘氨醇-1-磷酸）。数十种不同酶的协调活性维持这些脂质的适当水平和定位，在细胞过程中发挥关键作用。在这篇综述中，我们强调了鞘脂在细胞死亡和存活中的信号作用。我们讨论了最近的研究结果，在这些过程中的特定鞘脂的作用，使使用lipidomics研究这些脂质和合成鞘脂探针的组成和空间调控，研究亚细胞定位和相互作用的伙伴鞘脂了解这些脂质的功能。
Sphingolipids are highly bioactive lipids. Sphingolipid metabolism produces key membrane components (e.g. sphingomyelin) and a variety of signaling lipids with different biological functions (e.g. ceramide, sphingosine-1-phosphate). The coordinated activity of tens of different enzymes maintains proper levels and localization of these lipids with key roles in cellular processes. In this review, we highlight the signaling roles of sphingolipids in cell death and survival. We discuss recent findings on the role of specific sphingolipids during these processes, enabled by the use of lipidomics to study compositional and spatial regulation of these lipids and synthetic sphingolipid probes to study subcellular localization and interaction partners of sphingolipids to understand the function of these lipids.